New Experimental Strategy to Turn Off Immune Attacks in MS Uses “Nanoparticles”
November 19, 2012
Researchers funded by the National Institutes of Health have developed an innovative strategy for selectively inhibiting the immune attack in MS. Drs. Daniel R Getts, Aaron J Martin, and Stephen D Miller (Northwestern University, Chicago) report their results in Nature Biotechnology (advance online publication, November 18
When an immune cell dies, it releases chemicals that attract specific cells of the immune system called macrophages, which ingest the dying cell and deliver it to the spleen. Tiny portions of proteins from the dying cell are used to induce tolerance; this is a natural mechanism of the immune system to induce tolerance that somehow fails in MS. This team has developed ‘nanoparticles’ that can do the work of these proteins. Administered to mice with the MS-like disease EAE, the strategy reduced the attack on the brain and spinal cord. They are planning phase I clinical trials using this new technology.
in the press release from the National Institutes of Health (NIH). The research was supported by the NIH, the Myelin Repair Foundation, and the Juvenile Diabetes Research Foundation. Dr. Miller received funding from the Society for previous studies that led to this finding.