Indications, Dosing, Etc. - National Multiple Sclerosis Society

Skip to navigation Skip to content

Indications, Dosing, Etc.


In this article


This page lists FDA-approved DMTs: Indications, Dosing, Route of Administration, and Pregnancy Rating.

*Relapsing forms include relapsing-remitting MS (RRMS), secondary-progressive MS (SPMS), and progressive-relapsing MS (PRMS), in those patients who continue to have relapses.

Glatiramer acetate (Copaxone; Glatopa -- generic equivalent for 20mg dose)

Interferon b-1a (Avonex)

Interferon b-1b (Betaseron)

Interferon b-1a (Rebif)

Interferon b-1b (Extavia)

Pegylated Interferon b-1a (Plegridy)

  • Prescribing information
  • Indications:
    • Relapsing forms of MS
    • Dosing: 125 mcg q 14 days with initial titration (63 mcg Day 1; 94 mcg Day 15; 125 mcg Day 29 and q 14 days thereafter
  • Route of Administration: SQ
  • Pregnancy Category C

Dimethyl fumarate (Tecfidera)

Fingolimod (Gilenya)

Teriflunomide (Aubagio)

Alemtuzumab (Lemtrada)

  • Prescribing Information
  • Indications:
    • Relapsing forms of MS*
    • Generally reserved for patients who have had an inadequate response to two or more disease-modifying therapies
    • Study 1
    • Study 2
  • Dosing: 12 mg/day 5 consecutive days followed by 12 mg/day for 3 consecutive days one year later
  • Route of Administration: IV
  • Pregnancy Category: C


Mitoxantrone (Novantrone)

Natalizumab (Tysabri)


Diagnosis & Management Healthcare Professional App

Download this unique, FREE tool and resource that provides important information about the diagnosis and management of multiple sclerosis for practicing clinicians. The App is a concise compilation of current, easy-to-reference, evidence-based information that you can access at no charge as an Apple, Droid and Windows "App".

App production made possible by Allergan, Bayer HealthCare, Novartis and Questcor Pharmaceuticals, Inc.

Download for iPhone

Download for Android

Download for Windows Phone