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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Plant-Derived Oral Cannabinoid Spray to Treat Muscle Spasticity

    SUMMARY: Investigators are recruiting 446 people with MS worldwide who are being treated for spasticity for a study testing whether adding nabiximols (an oral spray), to ongoing antispasticity therapy can reduce MS-related muscle spasms. The study is sponsored by Jazz Pharmace...
  2. Clinical Trial: Comparing Experimental Fenebrutinib to Ocrevus® in Primary Progressive MS

    Investigators in the U.S. and abroad are recruiting 946 people with primary progressive MS for a study comparing investigational oral fenebrutinib with  Ocrevus ®  (ocrelizumab - Genentech, a member of the Roche Group). The study – also called FENtrepid – is sponsored by F. H...
  3. Clinical Trial: ofatumumab

    A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patient- reported outcomes in people with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy. FDA Approved medication (Brand na...
  4. Clinical Trial: Behavioral intervention for MS (via Zoom)

    Researchers at Kessler Foundation are studying whether a series of online classes based on cognitive behavioral therapy and positive psychology principles may improve self-efficacy, coping, psychological well-being, and quality of life in multiple sclerosis (MS). Participation...
  5. Clinical Trial: Behavioral intervention for MS (via Zoom)

    Researchers at Kessler Foundation are studying whether a series of online classes based on cognitive behavioral therapy and positive psychology principles may improve self-efficacy, coping, psychological well-being, and quality of life in MS. Participants are people who are di...
  6. Clinical Trial: Efficacy of Diet on Quality of life in MS

    We are recruiting for a new study that is being conducted at the University of Iowa!  People affected by relapsing remitting multiple sclerosis who are between the ages of 18 and 70 are invited to participate to evaluate the effects of three diets — Modified Paleolithic Eli...
  7. Clinical Trial: Ketamine for Multiple Sclerosis Fatigue (INKLING-MS)

    In this study, we aim to show the effect of ketamine on fatigue in 110 people with MS and fatigue, ages 18 to 65. Ketamine is a medication that indirectly increases the release of glutamate (an important chemical messenger) in the brain. We are recruiting 110 people with MS f...
  8. Clinical Trial Name: SCONE “CONTINENCE” CLINICAL STUDY

    The new SCONE device delivers non-invasive electric stimulation through electrodes on the skin along the spine and over the hips to stimulate the spinal cord. It modulates the central nervous system directly via the spinal cord. SCONE is a technique that enables electrical sti...
  9. Clinical Trial: Reducing fatigue in MS with transcutaneous electrical nerve stimulation (TENS)

    Purpose: To evaluate the effectiveness of treatment with transcutaneous electrical nerve stimulation (TENS) applied to leg muscles at reducing the level of fatigue experienced by people with MS.  Main Eligibility Requirements • Are between 18-65 yrs of age • Have a clini...
  10. Clinical Trial: Exercise Training, Cognition, and Mobility in Adults (50+ years) with MS

    Brief Description: Researchers are enrolling adults (50+ years of age) with MS for a remotely-delivered, home-based exercise training program for promoting cognition and physical function. What is this study about? The goal of this clinical trial is to examine the fe...
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