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International Progressive MS Alliance

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International Progressive MS Alliance

More than 2.3 million people worldwide currently live with MS. More than half, over 1 million people, live with a progressive form of MS.

Progressive multiple sclerosis is a form of MS that gets worse over time. Each day, progressive MS takes things away from people: vision, mobility, cognition, ability to work, and their very independence. Despite advances in other forms of MS, there are no treatments for progressive MS.

In this article

Life with Progressive MS

Louise, diagnosed in 1997

See what life is like with progressive MS and how the Progressive MS Alliance is working to change it.

Progressive MS lacks a single, identifiable disease pattern. As a result, researchers lack the knowledge needed to focus and accelerate progress. They lack tools to test how and why MS progresses, and too few new treatments are tested as a result of slow and costly trials.

People with progressive MS need solutions now – every day they live with the very real possibility of losing ground.

The Progressive MS Alliance

The Progressive MS Alliance is a growing global initiative to end progressive MS. The Alliance began by bringing together the world’s leading experts in multiple sclerosis to identify the critical knowledge and treatment gaps where progress must be made to achieve breakthroughs necessary to change the world for people with progressive MS.


  • In 2014 the first global Request for Applications for the Challenge Awards generated 195 responses from 21 different countries; 22 were awarded by the Alliance
  • A global progressive MS research portfolio has been developed to understand where and in what area current research is underway.
  • Alliance Member financial commitments for research is now at a total € 19.5 million (2015)
  • The Alliance has established and conducted two Industry Forum meetings, engaging industry stakeholders in moving solutions forward as Alliance members.


  • Eighty scientists and clinicians from around the world were convened in Boston by the Alliance to discuss what is known and not known about the chain of events and mechanisms leading to progressive MS.
  • • The second Request for Applications for planning grants to support Collaborative Network Awards closed in early 2015 resulting in applications for 52 different networks involving 480 researchers from around the world. The Scientific Steering Committee of the Alliance is evaluating all proposals and will determine awards for these Planning Grants later this summer. Applicants will be accepted from Planning Grant recipients in mid-2016 and grants for the Collaborative Network Awards will be awarded in late 2016.

The Alliance is Driving Progress in Three Important Ways

Global Leadership – ensuring that research is:

  1. Focused on barriers to treatment development
  2. Integrated across the MS community
  3. Systematically measured and refined


  1. Leveraging research already underway and stimulating new research and breakthroughs through a significant grants program.


  1. Drive worldwide resources to fund the best research, wherever it may be, and unleash the research community to accelerate results with the most impact and potential.

Members of the Alliance

The International Progressive MS Alliance continues to grow and expand. The Alliance is a global effort and today the members are:


  • MS Society of Australia
  • MS Society of Canada
  • Italian Multiple Sclerosis Association
  • MS International Federation
  • MS Society UK
  • National MS Society


  • MS Society of Belgium
  • Scleroseforeningen
  • German Multiple Sclerosis Society
  • Multiple Sclerosis Spain
  • Stichting MS Research

The members of the Alliance fund the research and drive the work of the Alliance including fundraising, research, communications etc. Learn more about the International Progressive MS Alliance.