DDAVP Nasal Spray - National Multiple Sclerosis Society

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DDAVP Nasal Spray


About this Medication
  • Brand Name: DDAVP Nasal Spray (U.S. and Canada)
  • Chemical Name: desmopressin (des-moe-press-in)
  • Usage in MS: Urinary Frequency
  • Generic Available: No


Desmopressin is a hormone used as a nasal spray. The hormone works on the kidneys to control frequent urination.

Proper Usage

Keep this medication in the refrigerator but do not allow it to freeze.


Let your physician know if you have heart disease, blood vessel disease, or high blood pressure. Desmopressin can cause an increase in blood pressure.

Studies have not been done in pregnant women. It has been used before and during pregnancy to treat diabetes mellitus and has not been shown to cause birth defects.

Desmopressin passes into breast milk but has not been reported to cause problems in nursing infants.

Possible Side Effects

Side effects that typically go away as your body adjusts to the medication and do not require medical attention unless they continue for several weeks or are bothersome: runny or stuffy nose; abdominal or stomach cramps; flushing of the skin; headache; nausea; pain in the vulva.

Unusual side effects that require immediate medical attention: confusion; convulsions; unusual drowsiness*; continuing headache; rapid weight gain; markedly decreased urination.

*Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of desmopressin, be sure to consult your health care professional if an abrupt change of this type occurs.