Oxytrol - National Multiple Sclerosis Society

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About this Medication
  • Brand Name: Oxytrol (Oxybutynin Transdermal System)
  • Chemical Name: oxybutynin (ox-i-byoo-ti-nin)
  • Usage in MS: Bladder Dysfunction
  • Generic Available: No


Oxybutynin is an antispasmodic that helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Oxytrol is a skin patch that delivers the active ingredient, oxybutynin, through your skin and into your bloodstream.

Proper Usage

A new patch is applied two times per week (every 3-4 days), with each patch worn until it is time to replace it with the next one. Only one patch is worn at a time.

The patch is placed on aclean, dry, and smooth area of the abdomen, hips, or buttocks.

The patch should not be put at the waistline, where it will be rubbed by tight clothing, or on areas of skin that have been treated with creams or oils that will prevent the patch from sticking.

Note: In January 2013, the FDA approved an over-the-counter (non-prescription) oxytrol patch for women over the age of 18 (Oxytrol for Women®)..Men still require a prescription to use any form of oxybutynin.

Warnings and Precautions

The FDA has added a warning to the labeling of this and other medications containing oxybutynin, stating that angioedema (a swelling similar to hives that occurs under the skin) of the face, lips, tongue and/or larynx has been reported with oxybutynin taken orally. In some cases, angioedema occurred after the first dose; in other cases it occurred with later doses. The swelling was severe enough in some individuals to interfere with breathing and required hospitalization and emergency treatment. Although this reaction appears to be relatively rare, given the many years that oxybutynin has been used safely and successfully by people with MS and others, any person taking a medication containing oxybutynin who experiences swelling of the tongue or throat or difficulty breathing should stop the medication and seek immediate medical attention.

This medication adds to the effects of alcohol and other central nervous system depressants (such as antihistamines, sedatives, tranquilizers, prescription pain medications, seizure medications, muscle relaxants). Be sure that your physician knows if you are taking these or any other medications.

This medication may cause your eyes to become more sensitive to light.

Oxybutynin may cause drying of the mouth. Since continuing dryness of the mouth can increase the risk of dental disease, alert your dentist if you are taking oxybutynin.

Oxybutynin has not been studied in pregnant women. It has not been shown to cause birth defects or other problems in animal studies. Any woman who wishes to become pregnant while using this medication should discuss it with her physician.

It is not known whether oxybutynin is excreted in breast milk. Since it tends to decrease body secretions, oxybutynin may reduce the flow of breast milk. Any woman who wishes to breastfeed while using this medication should discuss it with her physician.

Possible Side EffectsSide effects that typically go away as your body adjusts to the medication and do not require medical attention unless they continue for a few weeks or are bothersome: constipation*; decreased sweating; unusual drowsiness*; dryness of mouth, nose, throat; blurred vision*; decreased flow of breast milk; decreased sexual ability*; difficulty swallowing*; headache; increased light sensitivity; nausea or vomiting; trouble sleeping; unusual tiredness or weakness*.Less common side effects that should be reported to your physician immediately: difficulty in urination*.

*Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of oxybutynin, be sure to consult your healthcare professionals if an abrupt change of this type occurs.