Wellbutrin - National Multiple Sclerosis Society

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About this Medication
  • Brand Name: Wellbutrin
  • Chemical Name: bupropion (byoo-PROE-pee-on)
  • Usage in MS: Depression
  • Generic Available: No


Bupropion is used to treat mental depression.

Proper Usage

To lessen stomach upset, take this medication with food unless your physician has told you to take it on an empty stomach.

Before taking bupropion you should tell your physician if you use alcohol or take any of the following: antipsychotics; fluoxetine (Prozac); lithium (Lithane); trazodone (Desyrel); tricyclic antidepressants (these drugs in combination with bupropion may increase risk of seizures); monoamine oxidase inhibitors.

Before taking bupropion you should tell your physician if you have any of the following conditions: anorexia nervosa; brain tumor; bulimia; head injury; seizure disorder; bipolar disorder (manic-depression); heart disease; kidney disease; liver disease.


Do not stop taking bupropion without consulting your physician. The physician may want you to reduce the amount you are taking gradually in order to reduce the possibility of side effects.

Bupropion may cause drowsiness, dizziness, or a false sense of well being. Be sure you know how you react to bupropion before driving or using machinery.

Bupropion has not been studied in pregnant women. Birth defects have not been reported in animal studies.

Bupropion passes into breast milk. It should not be used during breastfeeding.

Possible Side Effects

Side effects that may go away as your body adjusts to the medication and do not require medical attention unless they persist for more than two weeks or are bothersome:

  • More common: constipation; loss of appetite; dizziness; dryness of mouth; increased sweating; nausea; vomiting; tremor*; weight loss.
  • Less common: blurred vision*; difficulty concentrating; drowsiness; fever or chills; hostility or anger; tiredness*; sleeping disturbances; euphoria.

Side effects that should be reported to your physician as soon as possible:

  • Common: agitation; anxiety; confusion; fast or irregular heartbeat; headache; restlessness; sleep disturbances.
  • Less common: hallucinations; skin rash.
  • Rare: fainting; seizures.

* Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of bupropion, be sure to consult your health care professional if an abrupt change of this type occurs.