Progressive-relapsing MS (PRMS) - National Multiple Sclerosis Society

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Progressive-relapsing MS (PRMS)

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Progressive-relapsing multiple sclerosis (PRMS) is the least common of the four disease courses, occurring in approximately five percent of people with MS. Like those with primary-progressive MS (PPMS), people with PRMS experience steadily worsening neurologic function — disease progression — from the very beginning, in addition to occasional relapses like those experienced by people with relapsing-remitting MS.

Because PRMS is progressive from onset, it may be initially diagnosed as PPMS, and then subsequently changed to PRMS when a relapse occurs. Although this disease course is progressive from the outset, each person’s symptoms and rate of progression will be different.

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