Symptoms and Diagnosis of HAM/TSP
What are the symptoms of HAM/TSP?
In response to the infection, the body's immune response may injure nerve tissue, causing a variety of symptoms.
- More than 90% of affected individuals will experience pain, stiffness and/or weakness in the legs, which can result in a tendency to trip or have trouble with stairs or getting out of a low chair.
More than 90% of affected individuals will experience urinary symptoms. Possible bladder abnormalities include:
- Increased frequency (the number of visits to the toilet to pass urine)
- Urgency (needing to pass urine with very little warning and often the volume of urine passed is small
- Nocturia (having to get up at night to pass urine more than once)
- Incontinence (not being able to get to the toilet in time
- Urinary retention (the bladder does not fully empty and more than the normal amount of urine remains in the bladder, which can lead to bladder infections and kidney infections)
- Bowel function can slow and result in constipation
- About 50% of people will have loss of feeling in the feet, tingling sensations, and unpleasant sensations when the skin is touched, and low back pain.
As many as 20% of people may also experience:
- Double vision
- Tendency to incorrectly estimate the amount of motion necessary to accomplish a specific task (dysmetria)
- Exaggerated reflexes
- Facial paralysis
- Inflammation of the nerves can also result in impotence or erectile dysfunction in men. :
How is HAM/TSP diagnosed?
- Blood test to detect antibodies to HTLV-1: While the presence of antibodies is essential for a diagnosis of HAM/TSP, it is not enough because most people with antibodies do not have HAM/TSP.
- Blood smears to detect flower cells (also seen in carriers).
- Spinal tap (lumbar puncture) to detect antibodies to HTLV-1 and to rule out other causes.
- MRI of the brain and spinal cord.
- Evoked potentials (EPs) to measure the electrical activity of the brain in response to stimulation of specific sensory nerve pathways. EPs are able to detect the slowing of electrical conduction caused by demyelination along these pathways even when the change is too subtle to be noticed by the person or to show up on neurologic examination.
- EMG-Electromyography to measures the electrical impulses of muscles.