What is it?
What is transverse myelitis?
- Transverse myelitis is a neurological disorder caused by inflammation (swelling) across both sides of one level or segment of the spinal cord. Inflammation can damage or destroy myelin, the fatty protective substance that covers nerve cell fibers. This damage causes scars that interrupt the communication between the nerves in the spinal cord and the rest of the body. Most people affected by transverse myelitis will have only one attack; a small percentage may have more than one attack.
Is transverse myelitis associated with other neurological diseases?
- Yes. Transverse myelitis can appear as the first symptom in conditions such as multiple sclerosis (MS) or neuromyelitis optica (NMO).
- A person with transverse myelitis who also has an abnormal brain MRI with more than two lesions has an increased chance (as high as 90%) of going to develop MS.
What is idiopathic transverse myelitis?
- If testing and examination does not suggest a specific cause for the condition, the diagnosis is presumed to be idiopathic transverse myelitis. No cause can be identified in 16-60% of people diagnosed with transverse myelitis.
What causes transverse myelitis?
- The exact cause of the damage to the spinal cord has not yet been determined with certainty but it is thought that it may be due to an autoimmune reaction to a viral or bacterial infection. In autoimmune diseases, the immune system mistakes the body’s own tissue as foreign, and attacks it, causing inflammation (swelling) that results in damage to the myelin.
An infection precedes the onset of transverse myelitis about 50% of the time
- Transverse myelitis often develops following viral infections such as varicella zoster (the virus that causes chicken pox and shingles), herpes simplex, cytomegalovirus, Epstein-Barr, influenza, echovirus, HIV, hepatitis A, and rubella.
- Bacterial skin infections, otitis media (middle-ear infections) and Mycoplasma pneumonia (bacterial pneumonia) have been associated with transverse myelitis
- Some cancers may trigger an abnormal immune response that my lead to transverse myelitis.
Who gets transverse myelitis?
Transverse myelitis occurs in adults and children, in males and females and in all races.
- Females have a higher risk of transverse myelitis than males.
- No genetic pattern is known. Transverse myelitis is not related to family history.
- It is estimated that about 1,400 new cases of transverse myelitis are diagnosed each year in the United States.
- It is estimated that about 33,000 Americans have some type of disability resulting from transverse myelitis.
- The annual incidence of TM ranges from 1.34 to 4.60 cases per million, but increases to 24.6 cases per million if acquired demyelinating diseases like MS and neuromyelitis optica (NMO) are included
At what age does transverse myelitis appear?
- The highest number of new cases in a given year occur between age 10 and 19 and between age 30 and 39 years.
How long does it take for the symptoms of transverse myelitis to appear?
- The symptoms of transverse myelitis can appear suddenly, developing over hours to several days or more gradually developing over a period of 1 to 4 weeks.