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CASE WESTERN RESERVE UNIVERSITY
Feng Lin, Ph.D.
Case Western Reserve University
Cleveland, Ohio
Category: Immunology
Project Number: RG 3664-A-1
Funding: $271,594
Term: 4/1/2005-9/30/2009
“Concurrent inhibition of T cell injury and complement attack in multiple sclerosis” Testing a strategy that may reduce MS-like disease in mice by inhibiting proteins that contribute to tissue damage.
Martha Miller, M.D., Ph.D.
Case Western Reserve University
Cleveland, Ohio
Category: Neurophysiology
Project Number: RG 3669-A-2
Funding: $538,712
Term: 4/1/2005-9/30/2009
“Proteolipid protein gene expression and function in the brainstem” Exploring whether gene activity related to a myelin protein makes respiratory nerve cells vulnerable in some people with MS.
CLEVELAND CLINIC FOUNDATION
Pallab Bhattacharyya, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Measuring MS Disease Activity
Project Number: RG 3753A1/2
Funding: $131,517
Term: 4/1/2007-9/30/2009
"Robust assessment of cerebral GABA levels in MS using MRS" Developing an imaging technique to detect levels of a nerve transmitter that may signify MS-related loss of nerve cells.
Astrid Cardona, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: TA 3021-A-1
Funding: $568,744
Term: 8/1/2006-7/31/2011
“Role of CX3CL1/CX3CR1 in neuroinflammation” Exploring an immune messenger chemical that may play a role in the immune attack that occurs in MS.
Robert Fox, M.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Therapy/Management of MS
Project Number: RG 3548A2/1
Funding: $567,434
Term: 10/1/2004-9/30/2009
"Defining the impact of methylprednisolone on brain tissue integrity in MS"; Testing whether advanced magnetic imaging can accurately track steroid treatment-related chances in nerve tissues and disease activity in MS.
Xiaoxia Li, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: RG 4056-A-1
Funding: $592,373
Term: 4/1/2008-3/31/2011
“IL-17 signaling in autoimmune demyelinating disease” Studying activities of a molecule that may aid in the immune attack in MS, and may be a good target for developing better treatments.
Mark Lowe, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Measuring MS Disease
Activity
Project Number: RG 3751-B-2
Funding: $305,529
Term: 4/1/2007-9/30/2009
“Functional assessment of white matter in MS” Using advanced imaging techniques to detect damage to nerve fibers in MS.
Wendy Macklin, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Biology of Glia
Project Number: RG 3819-A-8
Funding: $531,862
Term: 4/1/2006-9/30/2009
“CNS myelination induced by Akt” Investigating how a molecule in myelin-making cells may promote myelin production, for clues to stimulating myelin repair in MS.
Danette Nicolay, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Biology of Glia
Project Number: FG 1804-A-1
Funding: $143,723
Term: 7/1/2008-6/30/2011
“Retinoic acid's roles in oligodendrocyte development” Discerning the role of a molecule that may be critical to the development and repair of nerve-insulating myelin.
Carlos Pedraza, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Biology of Glia
Project Number: FG 1726A1/1
Funding: $156,515
Term: 7/1/2007-6/30/2010
“In vitro and in vivo induction of oligodendrocyte precursor maturation by small molecules” Discovering the potential of small molecules to rebuild myelin lost in MS.
Michael Phillips, M.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Psychosocial Aspects of MS
Project Number: RG 4110-A-2
Funding: $635,671
Term: 4/1/2008-3/31/2011
“FMRI & DTI evaluation of hippocampal damage and episodic memory loss in MS” Using high-tech imaging to investigate the relationship between damage to a part of the brain and cognitive impairment in people with MS.
Richard Ransohoff, M.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: RG 3980-A-5
Funding: $444,444
Term: 4/1/2007-3/31/2010
“Chemokines in CNS inflammation” The dual role of attractant molecules in the MS immune attack and in tissue repair.
Carine Savarin, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: FG 1791-A-1
Funding: $150,800
Term: 7/1/2008-6/30/2011
“Role of MMP9 in central nervous system inflammation” Understanding molecular steps that lead to the breakdown of the blood-brain barrier and permit the immune attack on the nervous system in MS.
Stephen Stohlman, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: RG 4007A4/1
Funding: $599,330
Term: 4/1/2008-3/31/2011
“IFN-g dependent astrocyte regulation of CNS autoimmunity” Can the little understood ability of brain cells called astrocytes to dampen immune attacks be harnessed to develop new therapies for MS?
Bruce Trapp, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: CNS Repair
Project Number: RG 3797A6/1
Funding: $457,199
Term: 10/1/2006-9/30/2009
“Neurogenesis in the lesions of MS” Seeking evidence that nerve cells in the brain and spinal cord have some capacity to regenerate in MS.
Vincent Tuohy, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: RG 3961A5/1
Funding: $501,105
Term: 10/1/2007-9/30/2010
“Regulated gene-based therapy for CNS demyelinating disease” Developing a novel gene therapy that would provide the DNA building blocks of interferon beta so that repeated injections would not be needed.
Chuanshen Wu, M.D., Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: CNS Repair
Project Number: FG 1781-A-1
Funding: $156,515
Term: 7/1/2007-6/30/2010
“Characterization of adult central nervous system stem cells” The potential of immature cells in the adult brain to produce myelin repair cells in MS.
Riqiang Yan, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Biochemistry/Biophysics
Project Number: RG 4012A1/1
Funding: $486,057
Term: 4/1/2008-3/31/2011
“The role of BACE1 in myelination” The role of a molecule in the repair of nerve insulating myelin, and whether blocking its activity blocks repair.
Anette van Boxel-Dezaire, Ph.D.
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: TA 3032A1/1
Funding: $569,494
Term: 7/1/2007-6/30/2012
“Altered cytokine signaling in multiple sclerosis” Determining how interferons influence immune cell activity in MS, for clues to better treatments.
Nobuhiko Ono, MD, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Award: Postdoctoral Fellowship
Funding: $150,800
Term: 7/1/09-6/30/12
"Axonal transport of mitochondria in myelination and demyelination" Clarifying the impacts of myelin loss on energy-producing functions of cells and the implications for treating MS.
Devon Conway, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Award: Sylvia Lawry Physician Fellowship
Funding: $195,000
Term: 7/1/09-9/30/12
"Clinical trials in multiple sclerosis" Receiving training from experts on designing and conducting clinical trials in people with MS.
THE OHIO STATE UNIVERSITY
Amy Lovett-Racke, Ph.D.
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 3812A3/T
Funding: $365,547
Term: 10/1/2006-9/30/2009
“Characterizing therapeutic targets for multiple sclerosis” Investigating a molecule that is critical to the development of immune cells that drive the attack in MS.
Amy Lovett-Racke, Ph.D.
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: JF 2116A1/1T
Funding: $318,837
Term: 10/1/2006-9/30/2009
“Role of t-bet in immune-mediated demyelinating disease” Testing a new approach to turning off immune cells specifically involved in the attack against myelin in MS-like disease.
Michael Racke, M.D.
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 3490A9/2T
Funding: $381,708
Term: 7/1/2007-3/31/2009
“Multiple sclerosis and infection: molecular mechanisms” Examining how infectious agents may trigger the immune attack in MS-like disease.
Michael Racke, M.D.
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 3427B10/1T
Funding: $449,576
Term: 4/1/2007-3/31/2010
“PPARalpha agonists as treatment for autoimmune demyelination” Exploring the potential of a compound for MS that already is used to treat cholesterol disorders.
Caroline Whitacre, Ph.D.
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 3687A5/1
Funding: $163,372
Term: 10/1/2005-9/30/2009
"The role of BACE1 in myelination" The role of a molecule in the repair of nerve-insulating myelin, and whether blocking its activity blocks repair.
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