Apr 29, 2013
Primary Investigator: Katie Siengsukon, PT, PhD, assistant professor in Physical Therapy and Rehabilitation Science Department at University of Kansas Medical Center
Background and Purpose:
Individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40% - 70% of patients with MS and can result in disability, unemployment, and reduced ability to perform daily activities. In addition, sleep problems in individuals with MS are very common, and approximately 50% of patients with MS have a sleep disorder. Physical and psychological factors such as pain, muscle spasms, medication side effects, anxiety, depression, bladder problems and disease severity all contribute to sleep disruption. Poor sleep quality has been associated with a reduction in several quality of life indices, including physical function, psychological well-being, self-care, work ability, and interpersonal relationships.
While evidence supports that aerobic exercise is associated with improved cognitive function and sleep quality in older individuals, the effect of aerobic exercise on cognitive function and sleep quality in individuals with multiple sclerosis is not known. Aerobic exercise could potentially be used as a treatment to address cognitive and sleep difficulties in MS. The findings of this study could potentially improve the quality of life of individuals with MS. Therefore, the purpose of this study is to determine the impact of a 3-month aerobic exercise program on cognitive function and sleep quality in individuals with MS.
Individuals with MS are being recruited to participate in this study. To participate in the study individuals must be 18-80 years old, have no untreated sleep disorders including sleep apnea or narcolepsy, and have been diagnosed with relapsing remitting or secondary progressive MS. You cannot participate in the study if you have experienced a relapse and/or corticosteroid use within four weeks.
Participants will undergo a baseline assessment at KUMC before being randomized into the aerobic exercise group or the home exercise group. The baseline assessment includes cardiovascular measures, sleep quality measures, cognitive function measures, and secondary outcome measures of depression, anxiety, fatigue, quality of life, and functional abilities The baseline assessment lasts 2-2.5 hours. After completing the baseline assessment, participants will be randomly assigned to either the aerobic exercise group or the home exercise group. The aerobic exercise group will perform supervised moderate aerobic exercise on a recumbent stepper 3x/week for 3 months at the University of Kansas Medical Center. Each session lasts about 45 minutes. The home exercise group will be prescribed a home exercise program to be performed 3x/week for 3 months. Each session of the home exercise program lasts about 45 minutes. Following 3 months of either aerobic exercise or home exercise, participants will undergo post-exercise assessment at KUMC consisting of the same measures that were conducted at the baseline assessment. The post-exercise assessment lasts 2-2.5 hours.
Participants in the AE group will be reimbursed $250 and the HE group will be reimbursed $150 to aid in recruitment efforts, help with retention, and to cover travel costs.
Contact: Catherine Siengsukon,email@example.com or 913-588-6913.