CASE WESTERN RESERVE UNIVERSITY
Sharyl Fyffe-Maricich, PhD
Case Western Reserve University
Cleveland, Ohio
Category: Biology of Glia
Project Number: FG 1877-A-1
Funding: $150,800
Term: 7/1/2010-6/30/2013
MAP kinase regulation of oligodendrocyte differentiation: The role of Erk2. Examining the role that an enzyme plays in the development of cells that can repair myelin, for clues to their stimulation in MS.
Yamming Wang, PhD
Case Western Reserve University
Cleveland, Ohio
Category: Measuring MS Disease Activity
Project Number: RG 4339-A-2
Funding: $445,548
Term: 11/1/2009-10/31/2012
Direct quantification of myelin changes in multiple sclerosis. Developing a sophisticated imaging technique to measure myelin repair in MS clinical trials.
CLEVELAND CLINIC FOUNDATION
Francois Bethoux, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Rehabilitation
Project Number: RG 3979A3/3
Funding: $274,868
Term: 10/1/2010-9/30/2012
Impact of hip flexion assist device on gait performance in multiple sclerosis. Evaluating a new device designed to aid walking in people with MS.
Pallab Bhattacharyya, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Measuring MS Disease Activity
Project Number: RG 4469-A-2
Funding: $333,609
Term: 10/1/2010-9/30/2012
Role of inhibitory neurotransmitter GABA in motor performance in MS. Studying how a molecule used by nerves to communicate with each other may contribute to physical disability in MS.
Devon Conway, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Therapy/Management of MS
Project Number: FP 1766-A-1
Funding: $195,000
Term: 7/1/2009-6/30/2012
Clinical trials in multiple sclerosis. Receiving training from experts on designing and conducting clinical trials in people with MS.
Robert Fox, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Measuring MS Disease Activity
Project Number: RC 1004-A-5
Funding: $571,260
Term: 7/1/2010-6/30/2012
A Multi-Modal Assessment of Chronic Cerebrospinal Venous Insufficiency. Understanding the role of CCSVI (vein blockage) in MS and identifying optimal methods for screening for the condition.
Robert Fox, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Measuring MS Disease Activity
Project Number: RG 4091A3/1
Funding: $682,630
Term: 7/1/2009-6/30/2012
A validation study of diffusion tensor imaging as a physiologically relevant biomarker of brain tissue integrity. Testing the ability of STI imaging as a way to track brain tissue injury, protection and repair for use in clinical trials. Funded in part by a gift from the National MS Society's South Central Region.
Nobuhiko Ono, MD, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Neuropathology
Project Number: FG 1834-A-1
Funding: $150,800
Term: 7/1/2009-6/30/2012
Axonal transport of mitochondria in myelination and demyelination. Clarifying the impacts of myelin loss on energy-producing functions of cells and the implications for treating MS.
Daniel Ontaneda, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Therapy/Management of MS
Project Number: FP 1769-A-1
Funding: $195,000
Term: 7/1/2010-6/30/2013
Sylvia Lawry Physician Clinical Fellowship. Developing the skills involved in the design, implementation, and analysis of clinical trials in multiple sclerosis.
Michael Phillips, MD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Psychosocial Aspects of MS
Project Number: RG 4110-A-2
Funding: $487,471
Term: 4/1/2008-3/31/2012
FMRI & DTI evaluation of hippocampal damage and episodic memory loss in MS. Using high-tech imaging to investigate the relationship between damage to a part of the brain and cognitive impairment in people with MS.
Stephen Stohlman, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: RG 4007A4/1
Funding: $569,363
Term: 4/1/2008-3/31/2012
IFN-g dependent astrocyte regulation of CNS autoimmunity. Can the little-understood ability of brain cells called astrocytes to dampen immune attacks be harnessed to develop new therapies for MS?
Bruce Trapp, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: CNS Repair
Project Number: RG 4007A4/1
Funding: $226,044
Term: 11/1/2009-10/31/2012
Cellular and molecular mechanisms of cortical remyelination in MS. Understanding why some sites of damage in the brain are repaired more readily than others during the course of MS. 2009 Stephen C. Reingold Award
Anette van Boxel-Dezaire, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Immunology
Project Number: TA 3032A1/1
Funding: $562,312
Term: 7/1/2007-10/31/2012
Altered cytokine signaling in multiple sclerosis. Determining how interferons influence immune cell activity in MS, for clues to better treatments.
Riqiang Yan, PhD
Cleveland Clinic Foundation
Cleveland, Ohio
Category: Biochemistry/Biophysics
Project Number: RG 4012A1/1
Funding: $461,754
Term: 4/1/2008-3/31/2012
The role of BACE1 in myelination. The role of a molecule in the repair of nerve-insulating myelin, and whether blocking its activity blocks repair.
THE OHIO STATE UNIVERSITY
Jacqueline Nicholas, MD
The Ohio State University
Columbus, Ohio
Category: Therapy/Management of MS
Project Number: FP 1777-A-1
Funding: $195,000
Term: 7/1/2011-6/30/2014
Multiple sclerosis fellowship in clinical trial investigation and expert clinical care of patients with MS. Developing the skills involved in the design, implementation, and analysis of clinical trials in MS.
Michael Racke, MD
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 4358A13/1
Funding: $468,954
Term: 10/1/2010-9/30/2013
Regulation of oxidative stress in autoimmune demyelination. Investigating a molecule in clinical trials to understand its influence on immune factors and how it may provide protection to the nervous system in MS.
Michael Racke, MD
The Ohio State University
Columbus, Ohio
Category: Immunology
Project Number: RG 3490A9/2T
Funding: $381,708
Term: 7/1/2007-3/31/2012
Multiple sclerosis and infection: molecular mechanisms. Examining how infectious agents may trigger the immune attack in MS-like disease.