Self-report studies suggest that women commonly experience transient worsening of their neurologic symptoms during the premenstrual (Voskuhl R & Giesser B 2011. Gender and reproductive issues. In Giesser (ed.) Primer on Multiple Sclerosis, NY: Oxford University Press).
Two studies – with conflicting results – have looked at the relationship between hormone levels over the course of the menstrual cycle and gadolinium-enhancing lesion activity on MRI (Bansil et al., 1999; Pozzilli et al., 1999).