Two question screen (Mohr et al., 2007) – has been shown to be reliable in identifying MS patients with major depressive disorder (MDD). Asking two brief questions could identify almost all MS patients meeting MDD criteria, with minimal numbers of false positives.
1. During the past two weeks, have you often been bothered by feeling down, depressed, or hopeless?
2. During the past two weeks, have you often been bothered by little interest or pleasure in doing things?
Of these options, the Goldman Consensus Statement on Depression in Multiple Sclerosis recommends the Beck Inventory, with a cutoff score of 13.