A wide variety of measures have been used in clinical studies of MS. Provided here is information about many of those most frequently used. Each measure includes a brief description, administration time, administration method, scoring method, general comments, information on the psychometric qualities of the measure, and literature citations. In addition, where possible, the actual forms needed to utilize the measure are provided.

• 9-Hole Peg Test (9-HPT)
• Ambulation Index (AI)
• Bladder Control Scale (BLCS)
• Bowel Control Scale (BWCS)
• Disease Steps (DS)
• Functional Systems Scores (FSS) and Expanded Disability Status Scale (EDSS)
• Health Status Questionnaire (SF-36)
• Impact of Visual Impairment Scale (IVIS)
• Mental Health Inventory (MHI)
• Modified Fatigue Impact Scale (MFIS)
• MOS Modified Social Support Survey (MSSS)
• MOS Pain Effects Scale (PES)
• Multiple Sclerosis Functional Composite (MSFC)
• Multiple Sclerosis Quality of Life-54 (MSQOL-54)
• Multiple Sclerosis Quality of Life Inventory (MSQLI)
• Paced Auditory Serial Addition Test (PASAT)
• Perceived Deficits Questionnaire (PDQ)
• Sexual Satisfaction Scale (SSS)
• Timed 25-Foot Walk (T25-FW)

Measures Indexed by Type**

Impairments of Body Functions and Body Structures

• 9-Hole Peg Test (9-HPT)
• Ambulation Index (AI) 
• Bladder Control Scale (BLCS)
• Bowel Control Scale (BWCS)
• Disease Steps (DS)
• Functional Systems Scores (FSS) and Expanded Disability Status Scale (EDSS)
• Multiple Sclerosis Functional Composite (MSFC)
• Paced Auditory Serial Addition Test (PASAT)
• Timed 25-Foot Walk (T25-FW)

Activity Limitations and Participation Restriction

• Impact of Visual Impairment Scale (IVIS)
• Mental Health Inventory (MHI)
• Modified Fatigue Impact Scale (MFIS)
• MOS Modified Social Support Survey (MSSS)
• MOS Pain Effects Scale (PES)
• Multiple Sclerosis Functional Composite (MSFC)
• Multiple Sclerosis Quality of Life-54 (MSQOL-54)
• Perceived Deficits Questionnaire (PDQ)
• Health Status Questionnaire (SF-36)
• Sexual Satisfaction Scale (SSS)

All of this material is reviewed on an annual basis and updated if needed. In addition, individual sections are updated whenever necessary.

**These measures are organized using the World Health Organization's International Classification of Functioning, Disability, and Health. The three major categories in the WHO system are

1. impairments of body functions and body structures
2. activity limitations and participation restriction
3. environmental factors

For information on the WHO classification system, visit the ICF home page at www3.who.int/icf/icftemplate.cfm.

Questions concerning clinical study measures should be directed to the Associate Vice President of Health Care Delivery and Policy Research at the National MS Society:

Nicholas LaRocca, PhD
212.476.0414
nicholas.larocca@nmss.org