The immune attack in MS unleashes a cascade of events that damage the wire-like arms of nerve cells (axons) and the insulating tissue (myelin) that wraps around axons, disrupting nerve signal transmission. Understanding the processes that lead to tissue damage in MS is crucial to feed parallel efforts to protect and repair the central nervous system. The MS Lesion Project was a major collaboration of investigators worldwide who sought to understand the damage MS does to the nervous system and ultimately improve its treatment. This large-scale project was funded through the Society’s Promise: 2010 Initiative.
Here is a sample of rehabilitation studies funded by the National MS Society:
- Frank Baas, MD, PhD (Academic Medical Center, Amsterdam) determining how an immune component, called complement, may worsen secondary-progressive MS.
- Steven LeVine, PhD (University of Kansas Medical Center, Kansas City) is investigating how changes in blood vessels may contribute to myelin damage in an MS model.
- Brian Popko, PhD (The University of Chicago) is using a newly developed model to uncover clues to factors that trigger myelin damage in MS.