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Details About 130 Clinical Trials in MS Now Available

June 7, 2011

We’re pleased to present our annual listing of Clinical Trials in MS 2011 (PDF), featuring ongoing MS trials, as well as those that are being planned or that have been recently completed. This year’s list of 130 studies indicates an exciting time in MS research, with therapies progressing through the drug development pipeline.

Here are some of the highlights:

  • Over 20 phase III studies are ongoing; these are the trials that provide the data presented to the U.S. Food and Drug Administration when sponsors file for drug approval. The largest of these trials are highlighted in a chart on page 2.
  • An increasing number of novel agents are being tested for neuroprotective capabilities, including antioxidants, green tea extracts, a drug used for pain relief, and the epilepsy drug phenytoin; two of these trials are funded by the National MS Society.
  • Nine trials are examining whether rehabilitation interventions (e.g., cycling) can improve symptoms including depression, mobility, spasticity and cognitive function. There were only two of these trials on the list in 2005.
  • Moving MS clinical research forward is not possible without people with MS; more than 52,000 people with all types of MS and those at high risk for MS participated, or are currently participating in these studies.

This list is prepared from materials provided by investigators, published literature and public presentations. While we strive for accuracy and completeness, there are trials that were not included because we were unable to gather sufficient information about them, and there may be inaccuracies due to changes in protocol.

Clinical Trial Participation Resources on Our Web Site

Because recruitment information changes frequently, we do not indicate which studies on this list are enrolling patients. For that information, go to the Clinical Trials section of our Web site, where there is a database of recruiting studies that is searchable by state, type of MS, or keyword, and MS Trial Alerts about specific studies. This section also includes a brochure and an online course to guide people through the process of deciding whether to enroll in a clinical trial.

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system. Symptoms range from numbness and tingling to blindness and paralysis, and there is currently no cure for MS. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. An estimated 1 million people live with MS in the United States. Most people with MS are diagnosed between the ages of 20 and 50, and it affects women three times more than men.


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