Gene That Boosts Resistance to Malaria linked to Susceptibility to MS and Lupus in Sardinia May 2, 2017 Researchers from Italy found a strong association between the gene that instructs the molecule “BAFF” and susceptibility to MS and lupus in studies of nearly 6,000 people in Sardinia. The BAFF gene is crucial to activation of immune B cells and is also associated with resistance to malaria. Malaria was common in Sardinia until it was eradicated in 1950. The rates of MS and certain immune-mediated diseases are high in Sardinia. Further research is necessary to confirm whether this high rate is related to BAFF, and whether MS could be treated by a therapy that targets BAFF. Read more about this study from the Genetic Literacy Project Read the scientific summary of the paper in The New England Journal of Medicine Read more about efforts to end MS forever