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MS Study Alert: Investigators Recruiting for Study Aimed at Individualizing Treatments for MS-Related Fatigue

January 31, 2018

SUMMARY: Investigators at Case Western Reserve University are recruiting 300 people nationwide who have MS and fatigue to examine factors that contribute to fatigue, for clues to developing individualized strategies for self management of fatigue. Participants are being asked to complete questionnaires several times over a three-month period. The study is funded through the Department of Defense Congressionally Directed Medical Research Programs.
Rationale: Fatigue is a common problem in people with MS. MS fatigue differs from normal fatigue in that it can occur daily, often after a good night's sleep. Self-management interventions have been shown to help people with MS manage their fatigue and improve quality of life. These involve learning strategies like taking rest breaks and knowing how and when to engage in physical activity. However, there is great variability in MS – individuals experience symptoms such as fatigue differently. This study is examining how a group of people with MS experience fatigue over time to identify the factors that influence fatigue and understand how to improve and personalize its treatment.
Eligibility and Details: With funding from the Department of Defense Congressionally Directed Medical Research Programs, Case Western researchers are recruiting for a three-month study on fatigue. Participants are people with MS, ages 18 to 76 years, who experience at least mild fatigue. They can live anywhere in the U.S., since no actual clinic visits are required. They are being asked to complete online questionnaires at the start of the study, after six weeks, and after three months. A subset of 120 participants will be randomly assigned to also wear an accelerometer (activity tracking device) and complete brief, daily questionnaires on a cell phone at random times throughout the day for 10 days upon enrollment in the study, and again three months later.
Contact: To learn more about the enrollment criteria for this study, and to find out if you are eligible to participate, please contact Emily Wang, by phone at 216-368-2181, or by email at
Without participants in research studies, MS research would come to a standstill. Read more here.

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.