National MS Society Invests in Commercial Research by TG Therapeutics for Development of Oral TGR-1202 (umbralisib) to Treat Progressive MS
October 2, 2017
The National MS Society, through Fast Forward, will invest up to $254,452 to enable TG Therapeutics, Inc. to further the laboratory testing of TGR-1202 (umbralisib) as a potential oral treatment option for progressive MS. Renowned MS researcher Dr. Lawrence Steinman, of Stanford University, will lead the research team on this effort.
This investment stemmed from a request for proposals released by Fast Forward for projects focused on testing existing therapies or drug candidates to determine if they protect the nervous system from damage and/or repair damage, especially for the treatment of progressive MS. TGR-1202 is already being tested in people with blood cancers, so it is ready for testing in MS if the lab testing suggests potential benefit.
“We are hopeful that these proof of concept studies will support the rationale for further clinical development of TGR-1202 for progressive forms of MS, for which there are few treatment options,” said Mark Allegretta, PhD, Associate Vice President of Commercial Research at the Society. “This investment exemplifies our effort to identify clinic-ready candidates to expand the pipeline of therapies being tested for use in MS.”
TGR-1202 uses a novel mechanism to inhibit the production of immune B cells, which are known to be involved in MS disease activity. Another B-cell therapy, Ocrevus™ (ocrelizumab - Genentech, a member of the Roche Group), was recently approved for both primary progressive and relapsing MS.
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Ocrevus is a Trademark of Genentech, a member of the Roche Group
Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS.
The National MS Society, founded in 1946, is the global leader of a growing movement dedicated to creating a world free of MS. The Society funds cutting-edge research for a cure, drives change through advocacy and provides programs and services to help people affected by MS live their best lives. Connect to learn more and get involved: nationalMSsociety.org, Facebook, X, formerly known as Twitter, Instagram, YouTube or 1-800-344-4867.