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Researchers from the University of Zurich and others report new findings on how immune system activity may get started in multiple sclerosis. They found that memory B cells (immune cells that normally help to fight infections) activate another type of immune cell called T cells, which are known culprits in immune attacks that result in brain and spinal cord damage in MS. The team also identified a protein produced by B cells that T cells react to. This study yields new information on the underlying mechanisms involved in MS, helps to explain how the disease-modifying treatment Ocrevus^® (ocrelizumab, Genentech, which depletes B cells) might work, and reveals new targets for the development of better treatments to stop the nervous system damage that causes MS symptoms and progressive disability.

Read more about the study on Science Daily

Read the paper, available via Open Access in the journal Cell