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New Study Sheds Light on How Immune B Cells May Activate MS

September 6, 2018

Researchers from the University of Zurich and others report new findings on how immune system activity may get started in multiple sclerosis. They found that memory B cells (immune cells that normally help to fight infections) activate another type of immune cell called T cells, which are known culprits in immune attacks that result in brain and spinal cord damage in MS. The team also identified a protein produced by B cells that T cells react to. This study yields new information on the underlying mechanisms involved in MS, helps to explain how the disease-modifying treatment Ocrevus® (ocrelizumab, Genentech, which depletes B cells) might work, and reveals new targets for the development of better treatments to stop the nervous system damage that causes MS symptoms and progressive disability.

Read more about the study on Science Daily

Read the paper, available via Open Access in the journal Cell
 

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.

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