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New Study Shows Potential for Cell Therapy to Repair Myelin in Mice

May 27, 2020

Researchers at the University of Rochester report in Cell Reports  that transplanting human brain cells into mice that have damage to nerve-insulating myelin can promote extensive repair and restore movement. The team transplanted immature cells that can develop into myelin-making and other key brain cells directly into the mice’s brains and then examined them up to 20 weeks afterward. They found extensive evidence of repair. The findings add evidence that, with further study, this strategy may help to restore function in progressive forms of MS, where the natural capacity for repairing myelin has stalled over time.

The Rochester team, led by Steve Goldman, MD, PhD, has launched a start-up company to translate these findings into clinical trials for disorders including MS, and the US Food and Drug Administration is currently reviewing data to determine if human trials can proceed.

Read more on the university website

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.

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