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Research Funded by the National MS Society Suggests Novel Path for Regulation of MS

August 7, 2019

A Stanford team has found that immune cells known for dousing infection or cancer might be exploited to stop the immune response that drives MS. The researchers injected mice with MS-like disease with proteins that activate and increase these suppressive CD8+ T cells, resulting in decreased inflammatory activity, and decreased disease activity.  Results were similar in blood samples obtained from people with MS. The team is working further to determine if such cells could be mobilized as a novel treatment for MS and other immune mediated diseases.

This research was supported by a Career Transition Award from the National MS Society to Naresha Saligrama, PhD, and by funding from the Howard Hughes Medical Institute, the National Institute of Allergy and Infectious Diseases, and the Simons Foundation.

Read more from Stanford University

Read a scientific summary of the paper in Nature

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.


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