Researchers Co-funded by National MS Society Report on New Way to Translate Lab Findings Aimed at Repairing Nerve-Insulating Myelin
August 18, 2017
With support from the National MS Society, University of Buffalo researchers compared genes for myelin-making cells in mice, rats, and people. Myelin surrounds nerve fibers, and is a target of the immune attack in MS. Strategies for promoting myelin repair sometimes succeed in mice or rats, and then not work in people, so this team used a new software tool to determine whether this was due to fundamental differences between species in the genes that instruct myelin formation. In the process, they identified a protein – GNB4 – that appears to be important to myelin formation in people. Further research is necessary to determine if GNB4 is a promising target for developing myelin repair strategies for MS.