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Researchers Show that a Molecule Produced by Gut Bacteria May Help To Regulate Immune Response in MS

March 18, 2020

Researchers in Germany showed that proprionic acid – a short chain fatty acid (a molecule produced by gut bacteria) – is reduced in people with MS and is associated with changes in the composition of gut bacteria (“gut microbiome”). In a 14-day clinical trial, they added proprionic acid supplements to ongoing MS medications in 91 people with MS and showed increases in immune cells called Tregs, which can turn down inflammation. Finally, they looked back at the records of 97 people with MS who had taken proprionic acid supplements for at least one year, and found evidence of reduced relapses and disability progression as compared to 57 who did not take proprionic acid supplementation; no serious adverse events were reported.

This is one of many emerging results that are shedding light on the role of the gut microbiome in MS and other disorders. More studies will help determine potential ways to alter the gut microbiome by diet, supplements, or other means in a way that may prove beneficial for people with MS.

Read more from the Ruhr-Universität Bochum

Read the scientific summary of the paper in Cell

About Multiple Sclerosis

Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.


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