Skip to navigation Skip to content

News

Share

Skin Cells Reprogrammed into Brain Cells Repair MS-like Damage in Mice

February 26, 2018

Researchers at the University of Cambridge and collaborators report that transplanting adult skin cells reprogrammed to become neural stem cells (specialized brain stem cells) reduced inflammation and damage to the nervous system in mice with MS-like disease. This type of success has been reported before, but this study identified the mechanism behind the benefits of transplanting the cells: the cells reduced the amount of “succinate,” a small molecule that sends inflammatory signals to immune cells.

This research was funded by the Wellcome Trust, European Research Council, Medical Research Council, Italian Multiple Sclerosis Association, Congressionally-Directed Medical Research Programs, the Evelyn Trust and the Bascule Charitable Trust.

Learn more about this research, from the University website

Read the paper online in Cell Stem Cell

Explore the potential of stem cells in MS

About Multiple Sclerosis

Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS.

Share


© 2022 The National Multiple Sclerosis Society is a tax exempt 501(c)3 nonprofit organization. Its Identification Number (EIN) is 13-5661935.