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Disease Courses


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Multiple sclerosis is a chronic, progressive disease that leads to increasing disability in most individuals. The vast majority (approximately 85 percent) of individuals present with a  relapsing-remitting course of the disease (Lublin et al., 2013). Most people with relapsing remitting MS transition to a more progressive course called secondary-progressive MS (SPMS) that is characterized by accumulation of disability with fewer relapses and inflammatory activity. About 10 to 15 percent of people with MS begin the disease with a progessive course, without relapses, known as primary progressive MS (PPMS).

Four disease courses have been identified in MS by the International Advisory Committee on Clinical Trials of MS in 2013 (Lublin et al., 2013).

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