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Disease Courses

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Overview

Multiple sclerosis is a chronic, progressive disease that leads to increasing disability in most individuals. The vast majority (approximately 85 percent) of individuals present with a  relapsing-remitting course of the disease (Lublin et al., 2013), and the majority of treatments are indicated for this type of MS. Most people with relapsing remitting MS transition to a more progressive course (secondary-progressive MS or SPMS) with a predominantly progessive course with fewer relapses and inflammatory activity.  About 10 to 15 percent of people with MS begin the disease with a progessive course, without relapses, known as primary progressive MS (PPMS).

Four disease courses have been identified in MS by the International Advisory Committee on Clinical Trials of MS in 2013 (Lublin et al.).

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