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Diagnostic Workup


Diagnostic workup for patients with suspected demyelinating disease: testing options

2017 McDonald MS Diagnostic Criteria- the diagnosis of MS requires elimination of more likely diagnosis and demonstration of dissemination of lesions in the CNS in space and time. 

Summary of testing options- for your patients with suspected demyelination disease

Prototypical MRI findings in MS-

  • When viewing this PDF, there will be notes about the MRIs being shown in the upper left corner of each page — just click on the small icon to view.  This is best done in Internet Explorer and Firefox.  Google Chrome is not able to properly display the PDF annotations.
  • If you are using Google Chrome, please access the prototypical MRI findings in MS (.ppt) version.

FDA Drug Safety Communication- FDA evaluating the risk of brain deposits with repeated use of gadolinium-based contrast agents for MRI

Consortium of MS Centers (CMSC) 2018 MRI Protocol And Clinical Guidelines For The Diagnosis And Follow-Up Of MS-  new to the CMSC MRI protocol and guidelines are recommendations of when to use gadolinium based contrast agents (GBCAs). They recommend using GBCAs in the following circumstances:

  • in patients presenting with a first clinical attack (CIS) to facilitate early diagnosis
  • in patients with highly active disease
  • in a patient whose condition is declining rapidly and unexplained
  • in a patient where the diagnosis is uncertain


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