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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Effect of Intermittent vs Continuous walking on gait kinematics in persons with MS

    Previous studies have shown that persons with MS have better gait endurance and less fatigue if they practice walking intermittently rather than continuously. The purpose of this study is to determine what is the difference in gait characteristics between intermittent and con...
  2. Clinical Trial: Complementary and Alternative Medicine Telerehabilitation Intervention

    The purpose of this study is to compare the effects of two delivery models of an evidence-based complementary alternative medicine (CAM) program that combines neurorehabilitative (functional) exercise, Yoga and Pilates for individuals with multiple sclerosis (MS).  CAM will be...
  3. Clinical Trial: transcranial direct current stimulation (tDCS)

    The goal of this study is to determine the effects of a tDCS on fatigue resistance in people with MS.  tDCS is a non-invasive brain stimulation in which a weak current increases a person’s ability to excite neurons in the brain. Previous work has shown that tDCS has benefici...
  4. Clinical Trial: People with MS using medical marijuana

    Investigators are recruiting people with MS who are using medical marijuana (it will not be provided to participants) to determine the effectiveness of medical marijuana use for the management of symptoms (fatigue, mobility) in people with MS. Click here for a screening for...
  5. Clinical Trial: Ocrelizumab

    An open-label, single-arm study to evaluate the effectiveness and safety of ocrelizumab in patients with early stage relapsing remitting multiple sclerosis.
  6. Clinical Trial: N-Acetyl Cysteine

    The study consists of two arms. The first arm of this study will receive intravenous and oral NAC, a strong antioxidant that increases brain glutathione. NAC, is the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. It has the potential to increase glutath...
  7. Clinical Trial: Leg strength asymmetries, mobility, and fatigue

    The goal of this study is to determine the association of differences in leg strength between the more and less affected side and walking performance and characteristics. The study involves two sessions (each 90-120 minutes) during which we will perform strength testing, a 6-m...
  8. Clinical Trial: High-dose cyclophosphamide

    Pilot study in aggressive MS
  9. Clinical Trial: Estriol

    A double-blind, placebo controlled trial to determine whether estriol treatment (added on to standard therapies) improves cognition in women with multiple sclerosis.
  10. Clinical Trial: Effect of Maximal Strength training on Gait and balance in persons with MS

    Subjects will undergo weight training using relatively high weights and low repetitions to determine the effect of this type of training on gait endurance, balance, and fatigue.
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