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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19


Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Effect of Intermittent vs Continuous walking on gait kinematics in persons with MS

    Previous studies have shown that persons with MS have better gait endurance and less fatigue if they practice walking intermittently rather than continuously. The purpose of this study is to determine what is the difference in gait characteristics between intermittent and con...

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  2. Clinical Trial: Effect of Maximal Strength training on Gait and balance in persons with MS

    Subjects will undergo weight training using relatively high weights and low repetitions to determine the effect of this type of training on gait endurance, balance, and fatigue.

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  3. Clinical Trial: Cognitive Rehabilitation Combined with Eye Movements

    This study is looking at how 12 weeks of computer-based cognitive rehabilitation may help improve memory and attention.  Key study eligibility requirements: Right handed adults diagnosed with RRMS. No relapses in the past 6 months. Noticeable decline in memory or other...

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  4. Clinical Trial: Suvorexant for Fatigue and Insomnia

    The MS Center at EvergreenHealth is conducting a randomized, double-blind, placebo-controlled, cross-over trial to assess the safety, tolerability, and efficacy of suvorexant (Belsomra®) in treating insomnia in adults with multiple sclerosis (MS) and fatigue. This study will a...

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  5. Clinical Trial: Treatment Strategies to Prevent Disability

    A study based at Johns Hopkins University is comparing two treatment strategies in 900 people newly diagnosed, or with onset/diagnosis in the past who have received minimal or no treatment, with the relapsing-remitting form of MS. The study is recruiting at approximately 45 ce...

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  6. Clinical Trial: Virtual Reality for MS

    Researchers are looking at the impact of virtual reality on walking for individuals with relapse and remitting Multiple Sclerosis. The intervention group will receive 18 sessions of Treadmill Training with Virtual Reality and the active control comparison will receive 18 tr...

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  7. Clinical Trial: Tracking Health in Multiple Sclerosis (TracMS)

    In Trac-MS researchers are interested in learning more about the relationship between everyday behaviors, thinking abilities, and brain health in people with relapsing-remitting multiple sclerosis and cognitive impairment, ages 30-59. Specifically, they are interested in exami...

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  8. Clinical Trial: Siponimod in advancing forms of relapsing MS

    Exploring the safety and tolerability of conversion from oral or injectable disease modifying therapies to dose-titrated Oral Siponimod in patients with advancing forms of relapsing multiple sclerosis. You, or someone you care for, may be able to take part if you/they: • are...

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  9. Clinical Trial: Effects of epidural and transcutaneous spinal stimulation

    Investigators are recruiting individuals with MS for a research study to compare the effects of epidural (invasive) and transcutaneous (non-invasive) spinal stimulation approaches to improve mobility. Participants will first undergo up to 3 experimental sessions with transcuta...

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  10. Clinical Trial: Tai Chi and Mindfulness Training

    Investigators are recruiting people with all subtypes of MS (participants need to capable of standing and moving unaided for a minimum of 15 minutes at a time) to investigate the impact of mindfulness training on balance and wellbeing in individuals with MS. This is a communit...

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