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Clinical Trial: Exploratory Study of Entire-body PET Scans for Multiple Sclerosis


Treatment mode of action: To improve monitoring
Number of Subjects: 20
Medication: PET scan (this is a research trial, not a study of an intervention)
Location: Arizona|California|Colorado|Nevada|Utah
Institutions: Brain Health Alliance (a 501c3 not-for-profit)
8 Gilly Flower St, Ladera Ranch, CA 92694 Contact Information
Carl Taswell, MD, PhD


Brain Health Alliance for monetary and management support;
Avid Radiopharmaceuticals for material support providing use of the Amyvid radiopharmaceutical;
collaborating medical imaging site at UC San Diego Imaging & Radiology for equipment and personnel support providing use of PET scanners.


Can an entire-body positron emission tomography (PET) scanner be used to improve evaluation, monitoring and measurement of both peripheral and central damage to nerve-insulating myelin (demyelination) in people with MS? We assume here that demyelination outside the brain may involve the spinal cord if not also possibly some of the larger peripheral nerves outside the spinal column in a manner that may be detected with the greater sensitivity and resolution of the most recent state-of-the-art PET scanners. Improved molecular imaging with new entire-body PET scanners that provide improved detection sensitivity and spatial resolution for quantitative  measurement of demyelination and remyelination will support better decision-making for patient care with more robust outcome measures for monitoring therapeutic drugs evaluated in clinical trials for the treatment of multiple sclerosis.

MS patients will be counseled for informed consent and screened for both the inclusion and exclusion criteria of the study. Those patients who agree to join the EPSMS Study will participate in online visits for televideo counseling sessions both before and after the PET scan. This medical imaging scan requires an onsite visit to UC San Diego Imaging & Radiology in La Jolla California. Prior to the PET scan, participants will be asked to provide urine and blood samples. The PET scan itself requires injection of the Amyvid imaging agent. Additional information detailing risks and benefits of the study may be found in the clinical trial protocol report available at 

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© 2023 The National Multiple Sclerosis Society is a tax exempt 501(c)3 nonprofit organization. Its Identification Number (EIN) is 13-5661935.