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Clinical Trial: Brain stimulation for overactive bladder

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Details
Type of MS: PPMS|PRMS|RRMS|SPMS
Treatment mode of action: To improve bladder function
Number of Subjects: 29
Medication: Magstim Rapid2 system
Location: Texas
Institutions: Houston Methodist Academic Institute
6565 Fannin, Houston, TX 77030 Contact Information
Hamida Rajab
713-363-9154
msbladder@houstonmethodist.org

Funding:

NIH, Office of the Director

Description

People with MS often experience a urinary bladder condition called Neurogenic Overactive Bladder (NOAB). People with NOAB often experience frequent urination, a sudden need to urinate, and even accidents. Instead of just focusing on the bladder, we want to see if we can improve the brain's role in controlling urination. Having already tested a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) in ten women with MS who have NOAB, we found it improved their bladder symptoms without any adverse side effects. By using this special type of brain stimulation, we hope to treat NOAB at the control source rather than only treat the symptoms and make the bladder work better. 

Eligibility
  • Women
  • 18 years or older
  • Clinically stable defined as Expanded Disability Status Score (EDSS) ≤ 7.5 without exacerbation worsening in the preceding 6 months prior to study entry 

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