Funding:

Description

Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect. 

This clinical trial will compare the effectiveness of 3 treatments for fatigue in MS: 1) a commonly used behavioral treatment strategy (telephone-based cognitive behavioral therapy (CBT), 2) a commonly used medication (modafinil), and 3) a combination of both therapies. Each participant will receive one of these 3 treatments for a total of 12 weeks.

Throughout the trial, participants will be given several short online surveys  to assess fatigue, sleep, and other symptoms. Before and after treatment, participants will wear a watch-like device for 7 days to measure symptoms as well as sleep and physical activity.  Study visits are currently being conducted via virtual visit using Zoom for Healthcare.