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Clinical Trial: Effects of epidural and transcutaneous spinal stimulation


Treatment mode of action: To improve mobility
Number of Subjects: 12
Medication: epidural and transcutaneous spinal stimulation
Location: Texas
Institutions: Houston Methodist Research Institute 
Address: 6560 Fannin St | Suite 944, Houston, TX 77030 Contact Information
Rachel Markley, MPH




Investigators are recruiting individuals with MS for a research study to compare the effects of epidural (invasive) and transcutaneous (non-invasive) spinal stimulation approaches to improve mobility. Participants will first undergo up to 3 experimental sessions with transcutaneous (non-invasive) spinal stimulation. Special stimulating electrodes will be placed on the skin of lower back and electrical current will be delivered to see induced responses in the leg muscles. Then, similar experimental procedures will be repeated using special electrodes implanted through the skin and placed over the dura (the protective coating) of the spinal cord. 
These electrodes will be implanted by a certified neurosurgeon and must be removed within 7 days. Each experimental session will last 3 hours. After two weeks following the epidural electrodes removal, participant will be evaluated to ensure they had no reactions to the procedures. Antibiotics will be prescribed during the study to avoid infection.


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