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Clinical Trial: Employment-Related Telephone Intervention for Pain Study (E-TIPS)


Treatment mode of action: To reduce pain
Number of Subjects: 200
Medication: telehealth pain self-management intervention
Location: Alabama|Alaska|Arizona|Arkansas|California|Colorado|Connecticut|Delaware|District of Columbia|Florida|Georgia|Hawaii|Idaho|Illinois|Indiana|Iowa|Kansas|Kentucky|Louisiana|Maine|Maryland|Massachusetts|Michigan|Minnesota|Mississippi|Missouri|Montana|Nebraska|Nevada|New Hampshire|New Jersey|New Mexico|New York|North Carolina|North Dakota|Ohio|Oklahoma|Oregon|Pennsylvania|Rhode Island|South Carolina|South Dakota|Tennessee|Texas|Utah|Vermont|Virginia|Washington|West Virginia|Wisconsin|Wyoming
Institutions: University of Washington (in partnership with Shirley Ryan AbilityLab)
  Contact Information
Kara Link


National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)


The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with multiple sclerosis who are employed. Participants from anywhere in the US will be randomly assigned to either E-TIPS or a waitlist control.

For those in the intervention group, eight, 45-minute telephone sessions will be delivered by a clinician. A patient workbook will be used to facilitate skill acquisition and rehearsal in and outside of sessions. The intervention includes education about the role of unhelpful thoughts, particularly pain catastrophizing, and unhelpful pain coping behaviors; instruction in how to identify and change unhelpful or negative thinking about pain; utilization of helpful coping strategies; relaxation techniques; behavioral activation including setting goals for physical activation, activity pacing and scheduling; and coping with pain flare-ups. Each session includes a brief relaxation exercise. Participants receive digital audio recordings of relaxation exercises to practice at home.

Participants assigned to the control group will continue to recieve standard care (a waitlist). Those in the control subjects will be offered the opportunity to receive the intervention following completion of the final 6-month follow-up assessment.

Outcomes, including pain interference, will be collected via an online survey at four timepoints during the study. Participants receive compensation for each survey they complete plus an additional bonus for completing all four surveys. No in-person visits are required.


© 2023 The National Multiple Sclerosis Society is a tax exempt 501(c)3 nonprofit organization. Its Identification Number (EIN) is 13-5661935.