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Clinical Trial: STEP for MS, an Exercise Intervention


Treatment mode of action: To improve mobility
Number of Subjects: 400
Medication: 16-week exercise program
Location: Alabama|Colorado|Georgia|Massachusetts|North Carolina|Ohio|Wisconsin
Institutions: Shepherd Center, Atlanta; University of Alabama, Birmingham; University of Georgia, Athens; Marquette University, Wisconsin; University of North Carolina, Chapel Hill; Cleveland Clinic, Ohio; University of Colorado, Denver; Massachusetts General Hospital, Boston, Massachusetts Contact Information
See site contact list below.


Patient-Centered Outcomes Research Institute (PCORI) 


New research shows that exercise is good for people with MS and may decrease symptoms and improve health and walking ability. An exercise study called STEP for MS will compare the outcomes of a 16-week exercise program conducted at home to a program conducted in a gym. A trained “coach” will help participants learn how to exercise and will provide encouragement throughout the program. 
Participants will exercise two times per week for about one hour each session for 16 weeks. Participants will take assessments before starting the program, two months into the program, at 16-weeks when the program ends, and at 6 and 12 months after starting the program.
Eligibility criteria: If you are between the ages of 18 and 65 years, you have MS, and can commit to driving to the study site for assessments and to exercise two times per week, you may qualify if you:
  • Can walk but you have some difficulty, with or without an assistive device
  • Do not exercise regularly
  • Have not had a relapse in the past month
  • Can commit to exercising 2 times a week for 16 weeks
  • Have reliable internet access
Site Contact list
For recruitment information:
Shepherd Center
Erica Sutton
Research Coordinator

University of Alabama, Birmingham
Petra Silic
Research Coordinator

University of Georgia, Athens
Megan Ware
Research Coordinator

Marquette University, Wisconsin
Heidi Feuling
Research Coordinator

University of North Carolina, Chapel Hill
Rachel Keen
Research coordinator

Cleveland Clinic, Ohio; 
Darlene Stough
Research Coordinator

University of Colorado, Denver
Holly Borland
Research recruitment specialist

Massachusetts General Hospital, Boston, Massachusetts
Dr. Plummer at 617-724-3103


© 2024 The National Multiple Sclerosis Society is a tax exempt 501(c)3 nonprofit organization. Its Identification Number (EIN) is 13-5661935.