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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Cognitive rehabilitation

    Participants will undergo neuropsychological testing as well as an electroencephalogram recording. Participants with multiple sclerosis will then receive cognitive rehabilitation twice a week for 12 weeks through RehaCom® (45 minutes per session).  RehaCom® training presents t...

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  2. Clinical Trial: ASPIRE (Aspirin for Exercise in Multiple Sclerosis)

    ASPIRE is a clinical trial to investigate aspirin as a treatment to improve exercise performance in people with MS who experience overheating during exercise.

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  3. Research Study: Mechanisms of Low Physical Work Capacity, Fatigue, and Reduced Mobility

    You are being asked to be a subject in a research study about blood flow regulation during exercise and how that may affect work capacity (the ability to perform exercise). This study will examine cardiac output (how much blood your heart can pump each minute) during a treadmi...

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  4. Clinical Trial: Ocrelizumab in MS

    This study is measuring the long-term effectiveness of ocrelizumab in people with progressive  and relapsing MS with novel composite disability endpoints, including No Evidence of Progression and No Evidence of Progression or Active Disease, in addition to a wide range of pati...

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  5. Clinical Trial: Multifaceted Fall Prevention Program in Non-Ambulatory People with MS

    The purpose of the proposed study is to examine the efficacy of a community-based rehabilitation educational intervention on management of falls in non-ambulatory individuals with MS (Multifaceted Fall Prevention Program, or MFPP) who use wheeled mobility devices. MFPP that ta...

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  6. Clinical Trial: Lipoic acid for Treatment of Progressive Multiple Sclerosis (LAPMS)

    Dr. Rebecca Spain, a neurologist at the VA Portland Health Care System, is conducting a multicenter study to see if the over the counter antioxidant, lipoic acid, helps multiple sclerosis (MS) and is safe to take in people with progressive forms of MS. They are looking for in...

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  7. Clinical Trial: Effects of epidural and transcutaneous spinal stimulation

    Investigators are recruiting individuals with MS for a research study to compare the effects of epidural (invasive) and transcutaneous (non-invasive) spinal stimulation approaches to improve mobility. Participants will first undergo up to 3 experimental sessions with transcuta...

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  8. Clinical Trial: Pear-006

    The ENABLE Study is evaluating an investigational digital intervention for people with relapsing MS who experience symptoms of depression. The intervention being evaluated in this study is downloaded to your mobile device and can be used to deliver treatment. It is a tool t...

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  9. Clinical Trial: Siponimod in MS

    To assess early phase safety and tolerability of converting from approved oral and injectable disease-modifying therapies for relapsing MS to siponimod. The results of this study will guide clinically relevant decisions related to the transition from frequently used therapies ...

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  10. Clinical Trial: Tai Chi and Mindfulness Training

    Investigators are recruiting people with all subtypes of MS (participants need to capable of standing and moving unaided for a minimum of 15 minutes at a time) to investigate the impact of mindfulness training on balance and wellbeing in individuals with MS. This is a communit...

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