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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Recumbent Stepping High Intensity Interval Training

    The Exercise Psychophysiology Laboratory from the Department of Kinesiology at Berry College is recruiting for a new study analyzing the effects of high intensity interval training on clinically relevant outcomes, like walking and cognition, in people with MS. The study is exa...
  2. Clinical Trial: Living in Full Even (LIFE) with Pain Study

    Chronic pain is a common and costly condition affecting millions of Americans. Chronic pain is also one of the most common symptoms associated with MS. Different types of treatment such as mindfulness meditation, cognitive therapy, and activation skills have been used to treat...
  3. Clinical Trial: Comparing Experimental Tolebrutinib with Placebo in Progressive MS

    SUMMARY: Investigators in the U.S. and abroad are recruiting a total of 2280 people with progressive forms of MS for two separate studies comparing investigational oral tolebrutinib with placebo. The studies – also called HERCULES and PERSEUS – are sponsored by Sanofi .   ...
  4. Clinical Trial: Examining the Neural Effects of a Behavioral Intervention for Physical Activity in MS -

    The Exercise Neuroscience Research Laboratory at the University of Alabama at Birmingham is currently recruiting for a research study to compare two behavioral interventions on modifying health behaviors in people who have MS. Participants will complete an MRI of the brain and...
  5. Clinical Trial: Evobrutinib in Relapsing MS

    Participation could last for up to 2 years and 4 months, with up to 26 study visits.  Evobrutinib will be compared to teriflunomide, a medication that is already used to treat RMS.  Participants will have an equal chance of receiving either the investigational medication or ...
  6. Clinical Trial: Ozanimod for Cognitive Function

    This is a multicenter, single-arm, open-label study to describe the change from baseline in cognitive processing speed in subjects with relapsing multiple sclerosis (RMS) treated with ozanimod HCl 1 mg at 3 years. All enrolled subjects will receive orally administered ozanimod...
  7. Clinical Trial: Evobrutinib Compared with Teriflunomide

    This study was designed to determine the efficacy and safety of evobrutinib in participants with relapsing MS. The primary objective will focus on reduction of relapses relative to teriflunomide over 96 weeks in adult participants with relapsing MS based on the Annualized Rela...
  8. Clinical Trial: Ozanimod for Cognitive Function

    This is a multicenter, single-arm, open-label study to describe the change from baseline in cognitive processing speed in subjects with relapsing multiple sclerosis (RMS) treated with ozanimod HCl 1 mg at 3 years. All enrolled subjects will receive orally administered ozanimod...
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