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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS

The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email to find out what information you need to submit for review.


Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Research Study: International MS Microbiome Study

    This study aims to understand the role of gut bacteria in MS, and by extension allows us to look at the effects of diet and environment on the gut microbiome and MS disease susceptibility and progression. For this study, we are asking that participants donate blood and stool ...
  2. Research Study: Seeking first degree relatives of people with MS for study of risk factors

    The goal of this study is to learn more about the causes of and risk factors for MS by studying first-degree relatives of people with MS and comparing them to people who are not first-degree relatives of someone with MS. We will use the data collected to develop a risk algorit...
  3. Clinical Trial: Treating Cognitive Deficits in MS With Transcranial Direct Current Stimulation

    Transcranial Direct Current Stimulation ( which involves low electrical current delivered via electrodes) has been used a therapy to improve language abilities in a number of neurological disease. This research study is looking for people with relapsing remitting multiple scle...
  4. Research Study: How lifestyle affects cognition

    Healthy lifestyle behaviors (e.g., exercise, cognitive stimulation, socialization) have been associated with maintaining cognitive health as we age. However, this has not be confirmed in the multiple sclerosis (MS) population. Therefore, the current study will investigate how ...
  5. Clinical Trial: Continued Current Therapy vs Transition to Ofatumumab After Neurofilament Elevation

    This is a multicenter, prospective study of up to 150 relapsing-remitting MS participants/ The study is looking to see if people who have not had a relapse in the past year would benefit from switching to ofatumumab. After giving consent, participants will have a one-week sc...
  6. Research Study: How Physical Disability and Race Combine to Affect Pregnancy

    Black people and Latinxs/Latinas with physical disabilities have unique experiences during pregnancy. To learn about these unique experiences, researchers at Brandeis University are conducting a research study. This study will help us to understand how both disability and ra...
  7. Research Study: Physical Activity and Biomarkers

    his pilot study examines if physical activity is associated with a blood biomarker of MS disease severity (neurofilament light chain), cognitive function, and vascular health in people with MS. Neurofilament light chain is a blood biomarker of damage in the central nervous sys...
  8. Clinical Trial: A Phase 1 Study of CAR T Cells in Participants with Relapsing or Progressive Forms of MS

    The purpose of this study is to evaluate the safety, tolerability, efficacy, and drug levels of CC-97540, the investigational therapy, in people with relapsing or progressive forms of MS. CAR T cell therapy is specifically manufactured for each individual patient using their o...
  9. Clinical Trial: Effect of Cooling on Balance Performance in MS

    The purpose of this study is to investigate the effectiveness of cooling on balance performance in persons with MS, ages 18-80 who are capable of standing unassisted for at least 1 minute. Previous studies have shown that cooling has improved walking in people with MS, however...
  10. Clinical Trial: High-Intensity, Dynamic-stability Gait Training in People With MS

    This study is being conducted to understand whether high intensity exercise and disturbances to balance can be used to improve walking and balance. Individuals that enroll in this study will be randomly assigned to one of four treadmill training groups. One group will conduct ...
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