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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Online program to increase physical activity

    Are you over 18 years old with an MS diagnosis (no flare ups in the last 30 days), exercise for 30 minutes or more at least 2 days per week for the last 6 months and would you like to help others with MS be more physically active? The Health Promotion and Rehabilitation Lab (p...
  2. Clinical Trial: Biomarker-Guided Combination Therapies for MS

    In people with MS, brain and cerebrospinal fluid biomarkers indicate inflammation or disease. Researchers at the National Institutes Health (NIH) seek volunteers with MS to see if 4 therapies given alone or combined affect MS biomarkers. They want to see if a change in biomark...
  3. Clinical Trial: ReCOVER – Clemastine Fumarate in Optic Neuritis

    WE ARE ACTIVELY RECRUITING PEOPLE EXPERIENCING A SUSPECTED OR DIAGNOSED ACUTE OPTIC NEURITIS IN AN EYE NOT PREVIOUSLY AFFECTED AND HAS YET TO RECEIVE STEROID TREATMENT FOR.    ReCOVER aims to assess the effect of clemastine as a myelin repair agent and its potential for th...
  4. Clinical Trial: Virtual Reality for MS

    Researchers are looking at the impact of virtual reality on walking for individuals with relapse and remitting Multiple Sclerosis. The intervention group will receive 18 sessions of Treadmill Training with Virtual Reality and the active control comparison will receive 18 tr...
  5. Clinical Trial: Tracking Health in Multiple Sclerosis (TracMS)

    In Trac-MS researchers are interested in learning more about the relationship between everyday behaviors, thinking abilities, and brain health in people with relapsing-remitting multiple sclerosis and cognitive impairment, ages 30-59. Specifically, they are interested in exami...
  6. Clinical Trial: Siponimod in advancing forms of relapsing MS

    Exploring the safety and tolerability of conversion from oral or injectable disease modifying therapies to dose-titrated Oral Siponimod in patients with advancing forms of relapsing multiple sclerosis. You, or someone you care for, may be able to take part if you/they: • are...
  7. Clinical Trial: Effects of epidural and transcutaneous spinal stimulation

    Investigators are recruiting individuals with MS for a research study to compare the effects of epidural (invasive) and transcutaneous (non-invasive) spinal stimulation approaches to improve mobility. Participants will first undergo up to 3 experimental sessions with transcuta...
  8. Clinical Trial: Tai Chi and Mindfulness Training

    Investigators are recruiting people with all subtypes of MS (participants need to capable of standing and moving unaided for a minimum of 15 minutes at a time) to investigate the impact of mindfulness training on balance and wellbeing in individuals with MS. This is a communit...
  9. Clinical Trial: Behavioral Intervention for Physical Activity in Multiple Sclerosis

    The Exercise Neuroscience Research Laboratory at the University of Alabama at Birmingham are currently recruiting for a National MS Society funded research study to compare two behavioral interventions on modifying and self-regulating health behaviors in people who have MS. Pa...
  10. Clinical Trial: Gut bacteria and MS

    The Yale-Griffin Prevention Research Center, the Multiple Sclerosis Treatment Center at Griffin Hospital, and Yale University are teaming up to study whether changing the bacteria in the gut can affect the process that leads to the development of multiple sclerosis (MS). This ...
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