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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Transcranial Direct Current Stimulation

    This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities, such as working memory. In this research, a device is used to deliver very weak electrical current to the surface of the scalp while partic...
  2. Clinical Trial: transcranial direct current stimulation (tDCS)

    The goal of this study is to determine the effects of a tDCS on fatigue resistance in people with MS.  tDCS is a non-invasive brain stimulation in which a weak current increases a person’s ability to excite neurons in the brain. Previous work has shown that tDCS has benefici...
  3. Clinical Trial: Tecfidera (Dimethyl Fumarate)

    An observational trial in which patients who are being newly prescribed dimethyl fumarate (Tecfidera) will be asked to follow their use with patient-responded outcome questionnaires.  
  4. Clinical Trial: Speed of Processing Training

    This study examines a technique to improve the time it takes to process information in people with MS. The study involves 2-3 hour test sessions (baseline, short-term follow up, long-term follow up) and a training program (2 one-hour sessions a week, 5 weeks). There is a 50/50...
  5. Clinical Trial: Progressive Muscle Relaxation Delivered Via Smartphone Application

    Investigators are recruiting people with MS and migraine to receive the RELAX intervention (Progressive Muscle Relaxation) delivered via a smartphone application or monitored usual care, to determine effects on pain and quality of life. 
  6. Clinical Trial: Shoe cushion for balance and gait

    Researchers from the Sensorimotor Neuroimaging Laboratory in the Department of Health and Exercise Science at Colorado State University are recruiting participants for a study to assess the effect of shoe cushion on balance and gait in females living with multiple sclerosis us...
  7. Clinical Trial: positive airway pressure therapy

    A randomized trial of positive airway pressure therapy to treat cognitive dysfunction in people with MS and obstructive sleep apnea. Read more here .
  8. Clinical Trial: People with MS using medical marijuana

    Investigators are recruiting people with MS who are using medical marijuana (it will not be provided to participants) to determine the effectiveness of medical marijuana use for the management of symptoms (fatigue, mobility) in people with MS. Click here for a screening for...
  9. Clinical Trial: Oral Ponesimod Added to Tecfidera

    Investigators are recruiting 600 people with relapsing MS for a clinical trial examining the effectiveness of adding ponesimod, an oral compound that affects immune function, in people who are still experiencing relapses while taking Tecfidera ® (dimethyl fumarate, Biogen, In...
  10. Clinical Trial: Ofatumumab vs. Teriflunomide

    A randomized, double-blind, double-dummy, parallel-group study comparing the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis.

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