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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Treatment Strategies to Prevent Disability

    A study based at Johns Hopkins University is comparing two treatment strategies in 900 people newly diagnosed, or with onset/diagnosis in the past who have received minimal or no treatment, with the relapsing-remitting form of MS. The study is recruiting at approximately 45 ce...
  2. Clinical Trial: Gaze and postural stability in persons with MS

    The objective of the study is to understand vision and balance stability and prevent falls in clinical populations. We want to understand how people stabilize their vision and posture during head and body movement and how treatment (exercise based training) may improve these s...
  3. Clinical Trial: Spasticity Management Program

    Participants will be placed randomly into one of two groups and will receive one of two different spasticity management programs. Each program consists of education and exercise training intended to help reduce spasticity. All participants will attend two 2-hour group se...
  4. Clinical Trial: Online program to increase physical activity

    Are you over 18 years old with an MS diagnosis (no flare ups in the last 30 days), exercise for 30 minutes or more at least 2 days per week for the last 6 months and would you like to help others with MS be more physically active? The Health Promotion and Rehabilitation Lab (p...
  5. Clinical Trial: Intranasal Insulin for Improving Cognitive Function

    This is a randomized, double-blind, placebo-controlled study in people with MS. This study will evaluate if giving insulin that is administered in the nostrils (intranasal) is safe and tolerable for people with MS. It is also being done to evaluate if intranasal insulin improv...
  6. Clinical Trial: Measurement and Training of Dual-Task of Gait

    TIRR Memorial Hermann and Texas Woman's University are currently recruiting for a rehabilitation-based study measuring dual-task of gait in people with MS and comparing the effectiveness of a specific dual-task gait intervention in improving the walking performance of people w...
  7. Clinical Trial: A COOL-MS Pilot Study

    Two of the most commonly reported symptoms of multiple sclerosis are fatigue and sensitivity to heat. Additionally, persons with multiple sclerosis (PwMS) often have greater difficulty performing cognitive and motor tasks simultaneously (i.e. walking and talking), presenting a...
  8. Clinical Trial: Biomarker-Guided Combination Therapies for MS

    In people with MS, brain and cerebrospinal fluid biomarkers indicate inflammation or disease. Researchers at the National Institutes Health (NIH) seek volunteers with MS to see if 4 therapies given alone or combined affect MS biomarkers. They want to see if a change in biomark...
  9. Clinical Trial: ReCOVER – Clemastine Fumarate in Optic Neuritis

    WE ARE ACTIVELY RECRUITING PEOPLE EXPERIENCING A SUSPECTED OR DIAGNOSED ACUTE OPTIC NEURITIS IN AN EYE NOT PREVIOUSLY AFFECTED AND HAS YET TO RECEIVE STEROID TREATMENT FOR.    ReCOVER aims to assess the effect of clemastine as a myelin repair agent and its potential for th...
  10. Clinical Trial: Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis

    This project studies the link between performance on sensitive computer-based measures of cognitive functioning (games that test reaction time) and findings on neuroimaging (brain scans with MRI and PET) for people who are new to receiving Tecfidera to manage their MS.  At the...
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