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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Methylphenidate, Modafinil and Amantadine for Fatigue

    This trial is a multicenter trial of 3 commonly used medications for treatment of multiple sclerosis related fatigue (amantadine, modafinil, methylphenidate) versus placebo. All the patients in the study will receive all 3 medications at different times to test their effective...

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  2. Clinical Trial: Discontinuation of Disease-Modifying Therapies (DMTs) in MS

    “Discontinuation of Disease Modifying Therapies (DMTs) in MS” is a multi-site research study funded by the Patient-Centered Outcomes Research Institute (PCORI) and led by Dr John Corboy at University of Colorado, Denver. Participants are individuals over the age of 55 who have...

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  3. Clinical Trial: Duavee, a tissue selective estrogen complex for menopausal symptoms

    The purpose of this study is to improve the quality of life for menopausal women with Multiple Sclerosis by investigating the effects of the hormonal drug Duavee on MS symptoms.   Participants will receive Duavee or placebo to take by mouth daily for 2 months at home. Duav...

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  4. Clinical Trial: Intranasal Insulin for Improving Cognitive Function

    This is a randomized, double-blind, placebo-controlled study in people with MS. This study will evaluate if giving insulin that is administered in the nostrils (intranasal) is safe and tolerable for people with MS. It is also being done to evaluate if intranasal insulin improv...

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  5. Clinical Trial: Measurement and Training of Dual-Task of Gait

    TIRR Memorial Hermann and Texas Woman's University are currently recruiting for a rehabilitation-based study measuring dual-task of gait in people with MS and comparing the effectiveness of a specific dual-task gait intervention in improving the walking performance of people w...

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  6. Clinical Trial: Oral Ponesimod Added to Tecfidera

    Investigators are recruiting 600 people with relapsing MS for a clinical trial examining the effectiveness of adding ponesimod, an oral compound that affects immune function, in people who are still experiencing relapses while taking Tecfidera ® (dimethyl fumarate, Biogen, In...

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  7. Clinical Trial: A COOL-MS Pilot Study

    Two of the most commonly reported symptoms of multiple sclerosis are fatigue and sensitivity to heat. Additionally, persons with multiple sclerosis (PwMS) often have greater difficulty performing cognitive and motor tasks simultaneously (i.e. walking and talking), presenting a...

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  8. Clinical Trial: Acute Intermittent Hypoxia

    Acute intermittent hypoxia is a breathing intervention that alternates brief bouts of breathing low and normal levels of oxygen. This treatment has successfully improved motor function in other populations with lower limb mobility difficulties, but has never been used in MS co...

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  9. Amantidine for Walking Impairment

    A 3-Arm, Multicenter, Double-Blind, Placebo-Controlled, Randomized Study to Assess the Efficacy and Safety of ADS-5102 Amantidine Extended Release Capsule in People with Multiple and Walking Impairment.

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  10. Clinical Trial: Ofatumumab

    12-week study for treatment of Relapsing MS, followed by a 4.5-year extension study. Qualifying participants will receive study medication and study related exams at no cost. Compensation will be provided for time and travel costs.  To qualify: Must be between 18-55 year...

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Learn About Clinical Trials

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Being There - MS Clinical Trials as Experienced by Some Volunteers (.pdf)

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