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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Pathological Basis of MRI Signal Changes in Multiple Sclerosis

    Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins. Researchers want to learn more about the stages of multiple sclerosis and follow...
  2. Research Study: Seeking first degree relatives of people with MS for study of risk factors

    The goal of this study is to learn more about the causes of and risk factors for MS by studying first-degree relatives of people with MS and comparing them to people who are not first-degree relatives of someone with MS. We will use the data collected to develop a risk algorit...
  3. Clinical Trial: Physical Activity Class – Online Program

    Dr. Chung-Yi Chiu at the University of Illinois is conducting a study on lifestyle changes to increase physical activity levels for people with multiple sclerosis.   This 8 week program is led by peer coaches with MS who are experienced in a physically active lifestyle. Th...
  4. Clinical Trial: Computerized Cognitive Training

    The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for people with MS. Participants would complete a set of tests (physical an...
  5. Clinical Trial: Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

    This study will evaluate the effectiveness and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS), including participants later in their disease course. This study focuses on upper limit disability progres...
  6. Clinical Trial: Increasing Physical Activity for Restless Legs Syndrome in Adults with MS

    This study is evaluating a 16 week internet-delivered program for increasing physical activity in adults with MS who have restless legs syndrome (RLS). Participants will attend two sessions at the lab; one before the program and one after the end of the program. Ultimately, th...
  7. Research Study: International MS Microbiome Study

    This study aims to understand the role of gut bacteria in MS, and by extension allows us to look at the effects of diet and environment on the gut microbiome and MS disease susceptibility and progression. For this study, we are asking that participants donate blood and stool ...
  8. Research Study: health behavior and wellness outcomes with wheelchair use

    Very little is known about health behaviors and the impact on symptoms in adults with MS who use wheelchairs. The Exercise Neuroscience Research Laboratory at the University of Alabama, Birmingham invites you to participate in a voluntary study of health behaviors in adults wi...
  9. Research Study: Pediatric RRMS

    Researchers are asking teens with MS and their siblings without MS between the ages of 12-18 to participate in an observational study.  With an MRI using a stronger magnet, a specialized picture of the brain, researchers at UTSW might predict an if an individual may have diffi...
  10. Clinical Trial: Coping and Adjusting to Living with MS (CALMS) Study

    This study, Coping and Adjusting to Living with Multiple Sclerosis or CALMS, is looking at whether a telephone-based wellness program, called Cognitive Behavioral Therapy for Uncertainty Tolerance in Multiple Sclerosis (MS), is helpful for adults over the age of 18 who are exp...
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