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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Research Study: health behavior and wellness outcomes with wheelchair use

    Very little is known about health behaviors and the impact on symptoms in adults with MS who use wheelchairs. The Exercise Neuroscience Research Laboratory at the University of Alabama, Birmingham invites you to participate in a voluntary study of health behaviors in adults wi...
  2. Research Study: Pediatric RRMS

    Researchers are asking teens with MS and their siblings without MS between the ages of 12-18 to participate in an observational study.  With an MRI using a stronger magnet, a specialized picture of the brain, researchers at UTSW might predict an if an individual may have diffi...
  3. Clinical Trial: Coping and Adjusting to Living with MS (CALMS) Study

    This study, Coping and Adjusting to Living with Multiple Sclerosis or CALMS, is looking at whether a telephone-based wellness program, called Cognitive Behavioral Therapy for Uncertainty Tolerance in Multiple Sclerosis (MS), is helpful for adults over the age of 18 who are exp...
  4. Clinical Trial: Community Health Study

    A research team at The University of Washington is inviting adults between the ages of 45-64 years old to participate in a research study. This study is for adults living with a long-term medical condition or physical disability that impacts day-to-day quality of life. Elig...
  5. Research Study: cognitive testing for MS

    Researchers are currently enrolling participants in a study of cognitive testing for Multiple Sclerosis. This study compares computerized and in-person cognitive testing, to see how well the results match. Participants will complete assessments of sensory, motor, and cognitive...
  6. Clinical Trial: Randomized controlled trial of intermittent fasting in multiple sclerosis

    The purpose of this study is to determine whether an intermittent fasting diet has beneficial effects in people with MS. This is a randomized clinical trial in 40 people with relapsing-remitting MS (RRMS) who are being treated with injectable (IFN, glatiramer acetate) or or...
  7. Clinical Trial: Siponimod in MS

    To assess early phase safety and tolerability of converting from approved oral and injectable disease-modifying therapies for relapsing MS to siponimod. The results of this study will guide clinically relevant decisions related to the transition from frequently used therapies ...
  8. Clinical Trial: Development of a Telehealth Obesity Intervention for People with MS

    This study is a behavioral telehealth program to help patients with MS who want to lose weight and live a healthier lifestyle.  Participants in this study will receive 24 weekly group phone counseling sessions. Each session will last approximately 60 minutes. In addition to...
  9. Research Study: Assessment of Portable Magnetic Resonance Imaging

    This study aims to examine the use of a novel portable MRI machine, which has been developed by physicists and physicians at the Massachusetts General Hospital. The MRI machine uses permanent magnets, meaning it doesn’t need liquid helium coolant, makes significantly less sou...
  10. Clinical Trial: Malignancies and MS Treatment

    VERISMO is a long-term, observational safety study of patients who are newly starting Ocrevus, or Lemtrada, Mavenclad, Tecfidera, Gilenya, Tysabri, or Aubagio. The goal of the study is to determine the full safety profile of Ocrevus compared to these other MS DMTs (disease mod...
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