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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: remibrutinib vs. teriflunomide for relapsing multiple sclerosis

    Remibrutinib inhibits an enzyme called “Bruton’s tyrosine kinase,” reducing the activation of B cells, which are immune cells that play a role in the response that affects the brain and spinal cord in MS.  This study is for participants diagnosed with relapsing multiple scl...

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  2. Clinical Trial: Treadmill training to reduce falls

    Falls present a serious challenge facing individuals affected by multiple sclerosis. This study aims to examine if and to what extent slip-based training can reduce the risk of falls for people with multiple sclerosis. The researchers are seeking adults (18-65 years old) with ...

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  3. Clinical Trial: Cannabidiol In People With MS: The Role Of Sleep And Pain (Cansleep-MS)

    Cannabidiol, the active ingredient in Epidiolex®, is a cannabinoid that naturally occurs in the Cannabis sativa L. plant.  Clinical trials suggest that cannabinoids (active compounds in Cannabis sativa) can be effective analgesics in individuals with chronic pain. Researche...

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  4. Clinical Trial: Efficacy of Diet on Quality of Life in MS

    Please see below for travel reimbursement information.  This is a research study comparing the effects of three diets — a Modified Paleolithic Diet (elimination of gluten, dairy, and eggs), a Time Restricted Olive Oil-based Ketogenic diet, and usual diet with informatio...

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  5. Clinical Trial: Comparing Experimental Tolebrutinib with Aubagio® in Relapsing MS

    PLEASE NOTE: ENROLLMENT IN THIS STUDY HAS BEEN PLACED ON HOLD IN THE UNITED STATES BY THE FDA DUE TO SOME CASES OF LIVER INJURY.  PLEASE SEE HERE FOR MORE INFORMATION.  SUMMARY: Investigators are recruiting a total of 1800 people with relapsing forms of MS worldwide for ...

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  6. Clinical Trial: Comparing Experimental Tolebrutinib with Placebo in Progressive MS

    PLEASE NOTE: ENROLLMENT IN THIS STUDY HAS BEEN PLACED ON HOLD IN THE UNITED STATES BY THE FDA DUE TO SOME CASES OF LIVER INJURY.  PLEASE SEE HERE FOR MORE INFORMATION.  SUMMARY: Investigators in the U.S. and abroad are recruiting a total of 2280 people with progressive f...

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  7. Clinical Trial: Employment-Related Telephone Intervention for Pain Study (E-TIPS)

    The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with multiple sclerosis who are employed. Participants from anywhere in the US will be randomly assigned to either E...

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  8. Clinical Trial: Probiotic for Urinary Symptoms Among People Who Use Catheters (Remote)

    To qualify for this study you must be 18 years or older, use an indwelling catheter OR Intermittent catheter, be diagnosed with MS, and have a history of 2 or more episodes of urinary symptoms or infection in the past year. Researchers at MedStar National Rehabilitation Hos...

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  9. Clinical Trial: Ocrelizumab vs. fingolimod in children and adolescents with MS

    Study is seeking to assess the safety and effectiveness of ocrelizumab (administered by intravenous infusion every 24 weeks) in comparison to fingolimod (one oral capsule taken once per day) in children and adolescents ages 10 to 18 with relapsing-remitting MS. The study is co...

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  10. Clinical Trial: A phase 1 safety study of ANK-700 in people with relapsing-remitting MS

    Study Rationale: Multiple sclerosis (MS) is a neurological disease that causes damage to the brain and spinal cord, and steadily worsens over time. As the central nervous system (CNS) controls most body functions, people living with MS can experience a wide range of symptoms. ...

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Being There - MS Clinical Trials as Experienced by Some Volunteers (.pdf)

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