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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Research Study: Physiologic dysfunction in MS-related Fatigue

    This research study is designed to assess whether physiologic dysfunction contributes to fatigue in people with MS. This connection will help guide routine neurological treatment fatigue in MS in the future.  Physiologic testing includes measurement of a person’s pupil functi...

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  2. Clinical Trial: Oral Ponesimod Added to Tecfidera

    Investigators are recruiting people with relapsing MS for a clinical trial examining the effectiveness of adding ponesimod, an oral compound that affects immune function, in people who are still experiencing relapses while taking Tecfidera ®  (dimethyl fumarate, Biogen, Inc.).

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  3. Online Survey: Healthcare Providers Sought for Survey on Exercise Promotion

    Researchers Funded by the National MS Society Seeking Healthcare Providers to Complete Survey on Exercise Promotion   Researchers at the Exercise Neuroscience Research Lab (ENRL), University of Alabama at Birmingham are developing a line of research to improve exercise p...

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  4. Clinical Trial: Cognitive rehabilitation

    Participants will undergo neuropsychological testing as well as an electroencephalogram recording. Participants with multiple sclerosis will then receive cognitive rehabilitation twice a week for 12 weeks through RehaCom® (45 minutes per session).  RehaCom® training presents t...

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  5. Clinical Trial: ASPIRE (Aspirin for Exercise in Multiple Sclerosis)

    ASPIRE is a clinical trial to investigate aspirin as a treatment to improve exercise performance in people with MS who experience overheating during exercise.

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  6. Research Study: Mechanisms of Low Physical Work Capacity, Fatigue, and Reduced Mobility

    You are being asked to be a subject in a research study about blood flow regulation during exercise and how that may affect work capacity (the ability to perform exercise). This study will examine cardiac output (how much blood your heart can pump each minute) during a treadmi...

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  7. Clinical Trial: Ocrelizumab in MS

    This study is measuring the long-term effectiveness of ocrelizumab in people with progressive  and relapsing MS with novel composite disability endpoints, including No Evidence of Progression and No Evidence of Progression or Active Disease, in addition to a wide range of pati...

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  8. Clinical Trial: Multifaceted Fall Prevention Program in Non-Ambulatory People with MS

    The purpose of the proposed study is to examine the efficacy of a community-based rehabilitation educational intervention on management of falls in non-ambulatory individuals with MS (Multifaceted Fall Prevention Program, or MFPP) who use wheeled mobility devices. MFPP that ta...

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  9. Clinical Trial: Effects of epidural and transcutaneous spinal stimulation

    Investigators are recruiting individuals with MS for a research study to compare the effects of epidural (invasive) and transcutaneous (non-invasive) spinal stimulation approaches to improve mobility. Participants will first undergo up to 3 experimental sessions with transcuta...

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  10. Clinical Trial: Pear-006

    The ENABLE Study is evaluating an investigational digital intervention for people with relapsing MS who experience symptoms of depression. The intervention being evaluated in this study is downloaded to your mobile device and can be used to deliver treatment. It is a tool t...

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Learn About Clinical Trials

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