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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Immune responses to COVID vaccines in people with MS on ocrelizumab

    It is not know whether people receiving ocrelizumab for MS mount adequate immune responses to COVID-19 vaccine. The study is designed to investigate B-cell and T-cell responses to COVID-19 vaccination in patients treated with Ocrevus.  There are 5 visits for this study. All...
  2. Clinical Trial: Ocrelizumab in Progressive MS (CONSONANCE)

    The purpose of the study is to see if Ocrelizumab will halt the worsening of the signs and symptoms of Progressive forms of MS. Smartphone-based “passive monitoring” of participants will also take place during the study. It will collect data on gait and mobility throughout the...
  3. Clinical Trial: Ofatumumab for Patients with Relapsing Multiple Sclerosis

    MS study evaluating the continued effectiveness, safety and tolerability of Ofatumumab in adults, between the ages 18-60, with relapsing multiple sclerosis who are transitioning from traditional anti-CD20 therapy. Click on this link to answer a few questions to see if you q...
  4. Clinical Trial: Ozanimod to Improve Cognitive Function

     Investigators are recruiting 250 people with relapsing forms of MS for a clinical trial to determine if ozanimod (Zeposia ® , Bristol Myers Squibb) improves cognitive functions, specifically information processing speed. The study is funded by Celgene. Read more
  5. Clinical Trial: Enhancing Energy in MS (ENERGY Study)

    People with multiple sclerosis (MS) often have problems with fatigue. For some people, fatigue is their most debilitating symptom of MS. Yet, many of the available treatments provide inadequate relief for fatigue. Past research has found that training in self-hypnosis is linke...
  6. Clinical Trial: Ofatumumab

    MS study to evaluate the effectiveness of ofatumumab after transitioning from oral therapy, in adults 18 to 60 with relapsing MS experiencing breakthrough disease.  Study participation includes in-person visits, blood draws, MRI appointments, and use of electronic devices and ...
  7. Clinical Trial: Comparing Ocrevus® to Placebo for Slowing the Progression of Upper Limb Disability in People with Primary Progressive MS

    nvestigators in the U.S. and abroad are recruiting 1000 people with primary progressive MS for a study comparing ocrelizumab (Ocrevus®) to placebo for slowing the progression of upper limb disability. The study – also called O’HAND – is sponsored by F. Hoffmann-La Roche. Rea...
  8. Clinical Trial: Sensory Stimulation for Neuromuscular Function and Balance in MS

      The purpose of this study is to investigate the influence of transcutaneous electrical nerve stimulation ( TENS ) on standing balance, strength, and force control in individuals with multiple sclerosis (MS). The project will include two evaluation sessions (visits) (appr...
  9. Clinical Trial: Low load resistance training using blood flow restriction for MS

    This research study proposes to investigate a strengthening program along with blood flow restriction to improve strength and mobility in people with multiple sclerosis who have walking limitations. The study will include 20 people with MS who need at least a cane to walk 100 ...
  10. Clinical Trial: ReCOVER – Clemastine Fumarate in Optic Neuritis

    WE ARE ACTIVELY RECRUITING PEOPLE EXPERIENCING A SUSPECTED OR DIAGNOSED ACUTE OPTIC NEURITIS IN A PREVIOUSLY UNAFFECTED EYE. VISUAL SYMPTOMS MUST BE WITHIN THE PAST 3 WEEKS AND THE PATIENT MUST BE STEROID NAIVE.  ReCOVER aims to assess the effect of Clemastine Fumarate as a...
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