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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: SAR442168

    This is a Phase 3, randomized, double-blind, 2-arm, placebo-controlled, parallel-group, multicenter, trial to determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis

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  2. Clinical Trial: SAR442168

     A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with nonrelapsing secondary progressive multiple sclerosis (HERCULES)  

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  3. Research Study: Fatigue

    Please note: This is not a clinical trial of an intervention, but rather a research study.  The purpose of this study is to systematically evaluate the relationship between fatigue severity, autonomic (involuntary) symptom burden, and autonomic physiological markers in MS p...

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  4. Clinical Trial: Cognitive Processing Speed Changes in Relapsing MS Treated With Ozanimod (RPC-1063)

    A study to determine if oral ozanimod can affect cognitive processing speed in people with relapsing MS. All subjects will receive orally administered ozanimod HCl 1 mg.  Please note: In response to the recent developments of the COVID-19 pandemic, sites are implementing me...

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  5. Clinical Trial: STEP for MS, an Exercise Intervention

    New research shows that exercise is good for people with MS and may decrease symptoms and improve health and walking ability. An exercise study called STEP for MS will compare the outcomes of a 16-week exercise program conducted at home to a program conducted in a gym. A train...

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  6. Clinical Trial: Ofatumumab

    A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patient- reported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy. FDA Approved medication (Brand na...

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  7. Clinical Trial: Probiotic for Urinary Symptoms Among People Who Use Catheters

    Researchers at MedStar National Rehabilitation Hospital are recruiting people who use indwelling or intermittent catheters for a two-part study. In the first part, investigators are taking 2 urine samples collected at least 2 weeks apart, and administering questionnaires about...

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  8. Clinical Trial: Physical Therapy to Prevent or Reduce Falls

    Dr. Michelle Cameron, a neurologist at OHSU and at the VA Portland Health Care System, is recruiting for the ADSTEP research study, which explores whether a training program on improving walking aid use can prevent and reduce falls in people with MS who use a walking aid. ...

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  9. Clinical Trial: Recumbent Stepping High Intensity Interval Training

    The Exercise Psychophysiology Laboratory from the Department of Kinesiology at Berry College is recruiting for a new study analyzing the effects of high intensity interval training on clinically relevant outcomes, like walking and cognition, in people with MS. The study is exa...

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  10. Clinical Trial: Examining the Neural Effects of a Behavioral Intervention for Physical Activity in MS -

    The Exercise Neuroscience Research Laboratory at the University of Alabama at Birmingham is currently recruiting for a research study to compare two behavioral interventions on modifying health behaviors in people who have MS. Participants will complete an MRI of the brain and...

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