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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS

The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email to find out what information you need to submit for review.


Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Probiotic for Urinary Symptoms Among People Who Use Catheters (Remote)

    To qualify for this study you must be 18 years or older, use an indwelling catheter OR Intermittent catheter, be diagnosed with MS, and have a history of 2 or more episodes of urinary symptoms or infection in the past year. Researchers at MedStar National Rehabilitation Hos...
  2. Clinical Trial: Ocrelizumab vs. fingolimod in children and adolescents with MS

    Study is seeking to assess the safety and effectiveness of ocrelizumab (administered by intravenous infusion every 24 weeks) in comparison to fingolimod (one oral capsule taken once per day) in children and adolescents ages 10 to 18 with relapsing-remitting MS. The study is co...
  3. Clinical Trial: A phase 1 safety study of ANK-700 in people with relapsing-remitting MS

    Study Rationale: Multiple sclerosis (MS) is a neurological disease that causes damage to the brain and spinal cord, and steadily worsens over time. As the central nervous system (CNS) controls most body functions, people living with MS can experience a wide range of symptoms. ...
  4. Clinical Trial: Plant-Derived Oral Cannabinoid Spray to Treat Muscle Spasticity

    SUMMARY: Investigators are recruiting 446 people with MS worldwide who are being treated for spasticity for a study testing whether adding nabiximols (an oral spray), to ongoing antispasticity therapy can reduce MS-related muscle spasms. The study is sponsored by Jazz Pharmace...
  5. Clinical Trial: Exploratory Study of Entire-body PET Scans for Multiple Sclerosis

    Can an entire-body positron emission tomography (PET) scanner be used to improve evaluation, monitoring and measurement of both peripheral and central damage to nerve-insulating myelin (demyelination) in people with MS? We assume here that demyelination outside the brain may i...
  6. Clinical Trial: Fenebrutinib

    A study to evaluate the effectiveness and safety of fenebrutinib on disability progression and relapse rate. Eligible participants will be randomly assigned to receive either fenebrutinib or teriflunomide. Some may then  receive fenebrutinib during an open label extension.
  7. Clinical Trial: Comparing Experimental Fenebrutinib to Aubagio® in Relapsing MS

     Investigators in the U.S. and abroad are recruiting a total of 1468 people with relapsing forms of MS for two separate studies comparing investigational oral fenebrutinib with Aubagio ® (teriflunomide, Sanofi Genzyme). The studies – also called FENhance – are sponsored by F....
  8. Clinical Trial: Comparing Experimental Fenebrutinib to Ocrevus® in Primary Progressive MS

    Investigators in the U.S. and abroad are recruiting 946 people with primary progressive MS for a study comparing investigational oral fenebrutinib with  Ocrevus ®  (ocrelizumab - Genentech, a member of the Roche Group). The study – also called FENtrepid – is sponsored by F. H...
  9. Clinical Trial: ofatumumab

    A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patient- reported outcomes in people with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy. FDA Approved medication (Brand na...
  10. Clinical Trial: Behavioral intervention for MS (via Zoom)

    Researchers at Kessler Foundation are studying whether a series of online classes based on cognitive behavioral therapy and positive psychology principles may improve self-efficacy, coping, psychological well-being, and quality of life in multiple sclerosis (MS). Participation...
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