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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Examining the Neural Effects of a Behavioral Intervention for Physical Activity in MS -

    The Exercise Neuroscience Research Laboratory at the University of Alabama at Birmingham is currently recruiting for a research study to compare two behavioral interventions on modifying health behaviors in people who have MS. Participants will complete an MRI of the brain and...
  2. Clinical Trial: Cognitive Processing Speed Changes in Relapsing MS Treated With Ozanimod (RPC-1063)

    A study to determine if oral ozanimod can affect cognitive processing speed in people with relapsing MS. All subjects will receive orally administered ozanimod HCl 1 mg. 
  3. Research Study: Physiologic dysfunction in MS-related Fatigue

    This research study is designed to assess whether physiologic dysfunction contributes to fatigue in people with MS. This connection will help guide routine neurological treatment fatigue in MS in the future.  Physiologic testing includes measurement of a person’s pupil functi...
  4. Clinical Trial: Evobrutinib vs. teriflunomide in Relapsing MS

    Investigators in the U.S. and abroad are recruiting a total of 1860 people with relapsing forms of MS for two separate studies comparing investigational oral evobrutinib with Aubagio® (teriflunomide, Sanofi Genzyme). Read more
  5. Clinical Trial: BIIB017 (peginterferon beta-1a) in children and teens with MS

    This study aims to evaluate the safety, tolerability, and effectiveness of BIIB017 for the treatment of children and teens ages 10 to less than 18 with relapsing-remitting MS. Participants will take BIIB017 (peginterferon beta-1a) or Avonex (interferon beta-1a). Participation ...
  6. Clinical Trial: Effects of Opal Cool Wrap on Symptoms and Quality of Life in Women with MS

    Study Title: Effects of Opal Cool Wrap on Symptoms and Quality of Life in Women with Multiple Sclerosis   Researchers at St. Catherine University are seeking women participants with multiple sclerosis (MS) to determine the effectiveness of the Opal Cool Wrap (an external...
  7. Clinical Trial: SleepWell! with MS

    Disrupted sleep is common among adults with MS. A new iPhone/iPad app (SleepWell! with MS) has been developed that will allow adults with MS to access mindfulness and sleep education from their own personal Apple devices. During this study, participants will practice meditatio...
  8. Clinical Trial: Robotic exoskeleton

    The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton (RE) device, called Ekso-GT, to improve learning, memory and walking ability in persons with walking disability due to Multiple Sclerosis. The study will evaluate the mobility, l...
  9. Clinical Trial: Spasticity Management Program

    Participation online via video conferencing is now available. Participants will be placed randomly into one of two groups and will receive one of two different spasticity management exercise programs. Each program consists of education and exercise training intended to help re...
  10. Clinical Trial: Fenebrutinib

    A study to evaluate the effectiveness and safety of fenebrutinib on disability progression and relapse rate. Eligible participants will be randomly assigned to receive either fenebrutinib or teriflunomide. Some may then  receive fenebrutinib during an open label extension.
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