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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: A Low-Fat Diet for Fatigue in MS

    Dr. Vijayshree Yadav, a neurologist at Oregon Health & Science University, is conducting a study to see if following a low fat diet can help decrease fatigue in people with multiple sclerosis. We are looking for individuals 18-70 years old who are not already following a low-f...
  2. Clinical Trial: Treatment Strategies to Prevent Disability

    A study based at Johns Hopkins University is comparing two treatment strategies in 900 people newly diagnosed, or with onset/diagnosis in the past who have received minimal or no treatment, with the relapsing-remitting form of MS. The study is recruiting at approximately 45 ce...
  3. Clinical Trial: Opicinumab (BIIB033)

    The objective of this study is to evaluate the efficacy and safety of BIIB033 used as add-on therapy to anti-inflammatory disease-modifying therapies (DMTs) in subjects with relapsing multiple sclerosis (RMS). BIIB033 is human monoclonal antibody directed against the LINGO-1 p...
  4. Clinical Trial: Gaze and postural stability in persons with MS

    The objective of the study is to understand vision and balance stability and prevent falls in clinical populations. We want to understand how people stabilize their vision and posture during head and body movement and how treatment (exercise based training) may improve these s...
  5. Clinical Trial: Arbaclofen extended release tablets

    This is a study to evaluate the safety and tolerability of oral arbaclofen extended release tablets in patients with spasticity due to MS. 
  6. Clinical Trial: Spasticity Management Program

    Participants will be placed randomly into one of two groups and will receive one of two different spasticity management programs. Each program consists of education and exercise training intended to help reduce spasticity. All participants will attend two 2-hour group se...
  7. Clinical Trial: Online program to increase physical activity

    Are you over 18 years old with an MS diagnosis (no flare ups in the last 30 days), exercise for 30 minutes or more at least 2 days per week for the last 6 months and would you like to help others with MS be more physically active? The Health Promotion and Rehabilitation Lab (p...
  8. Clinical Trial: Methylphenidate, Modafinil and Amantadine for Fatigue

    This trial is a multicenter trial of 3 commonly used medications for treatment of multiple sclerosis related fatigue (amantadine, modafinil, methylphenidate) versus placebo. All the patients in the study will receive all 3 medications at different times to test their effective...
  9. Clinical Trial: Discontinuation of Disease-Modifying Therapies (DMTs) in MS

    “Discontinuation of Disease Modifying Therapies (DMTs) in MS” is a multi-site research study funded by the Patient-Centered Outcomes Research Institute (PCORI) and led by Dr John Corboy at University of Colorado, Denver. Participants are individuals over the age of 55 who have...
  10. Clinical Trial: Duavee, a tissue selective estrogen complex for menopausal symptoms

    The purpose of this study is to improve the quality of life for menopausal women with Multiple Sclerosis by investigating the effects of the hormonal drug Duavee on MS symptoms.   Participants will receive Duavee or placebo to take by mouth daily for 2 months at home. Duav...
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