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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Computerized Cognitive Training

    The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for people with MS. Participants would complete a set of tests (physical an...
  2. Clinical Trial: Virtual Reality Treadmill Training for MS

    This study is testing whether a 6 week virtual reality treadmill exercise program with a trained therapist improves mobility and cognitive function.  Compensation is provided.  Available for individuals diagnosed with relapsing remitting MS and between ages of 18 and 65.   ...
  3. Clinical Trial: Multifaceted Fall Prevention Program for People with MS who Use Wheelchairs or Scooters

    The purpose of the proposed study is to examine the effectiveness of a community-based rehabilitation educational intervention on management of falls in non-ambulatory individuals with MS (Multifaceted Fall Prevention Program). Programs that target both physiological and behav...
  4. Clinical Trial: Mindfulness-based intervention to relieve symptoms

    The purpose of this research study is to test the effects of a nurse-inspired, web-based mindfulness based expressive art therapy in persons with MS. To qualify, signed informed consent is needed, along with collection of saliva for cytokine and body temperature. The web-based...
  5. Clinical Trial: Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

    This study will evaluate the effectiveness and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS), including participants later in their disease course. This study focuses on upper limit disability progres...
  6. Clinical Trial: Increasing Physical Activity for Restless Legs Syndrome in Adults with MS

    This study is evaluating a 16 week internet-delivered program for increasing physical activity in adults with MS who have restless legs syndrome (RLS). Participants will attend two sessions at the lab; one before the program and one after the end of the program. Ultimately, th...
  7. Clinical Trial: Skeletal Muscle Blood Flow During Exercise in Persons with MS

    Previous studies have shown that people with MS may have impaired blood pressure and heart rate responses to standard tests. The systems that regulate heart rate and blood pressure responses are important to properly distribute blood flow to active muscle during exercise or ph...
  8. Research Study: looking at causes of fatiguing illness including MS

    This is an observational study looking at a symptomatic, immune function and inflammatory markers of disease with respect to fatiguing illnesses and their potential causes.  Participants will be asked to fill out a set of questionnaires, contribute saliva and blood, and have a...
  9. Research Study: International MS Microbiome Study

    This study aims to understand the role of gut bacteria in MS, and by extension allows us to look at the effects of diet and environment on the gut microbiome and MS disease susceptibility and progression. For this study, we are asking that participants donate blood and stool ...
  10. Research Study: health behavior and wellness outcomes with wheelchair use

    Very little is known about health behaviors and the impact on symptoms in adults with MS who use wheelchairs. The Exercise Neuroscience Research Laboratory at the University of Alabama, Birmingham invites you to participate in a voluntary study of health behaviors in adults wi...
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