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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Physical Therapy to Prevent or Reduce Falls

    Dr. Michelle Cameron, a neurologist at OHSU and at the VA Portland Health Care System, is recruiting for the ADSTEP research study, which explores whether a training program on improving walking aid use can prevent and reduce falls in people with MS who use a walking aid. ...
  2. Clinical Trial: Cognitive Behavioral Therapy, Modafinil, or Both for MS Fatigue ("COMBO-MS")

    Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect.  This clinical trial will compare the effectivenes...
  3. Clinical Trial: Recumbent Stepping High Intensity Interval Training

    The Exercise Psychophysiology Laboratory from the Department of Kinesiology at Berry College is recruiting for a new study analyzing the effects of high intensity interval training on clinically relevant outcomes, like walking and cognition, in people with MS. The study is exa...
  4. Clinical Trial: Living in Full Even (LIFE) with Pain Study

    Chronic pain is a common and costly condition affecting millions of Americans. Chronic pain is also one of the most common symptoms associated with MS. Different types of treatment such as mindfulness meditation, cognitive therapy, and activation skills have been used to treat...
  5. Clinical Trial: Examining the Neural Effects of a Behavioral Intervention for Physical Activity in MS -

    The Exercise Neuroscience Research Laboratory at the University of Alabama at Birmingham is currently recruiting for a research study to compare two behavioral interventions on modifying health behaviors in people who have MS. Participants will complete an MRI of the brain and...
  6. Clinical Trial: Ozanimod for Cognitive Function

    This is a multicenter, single-arm, open-label study to describe the change from baseline in cognitive processing speed in subjects with relapsing multiple sclerosis (RMS) treated with ozanimod HCl 1 mg at 3 years. All enrolled subjects will receive orally administered ozanimod...
  7. Clinical Trial: Cognitive Processing Speed Changes in Relapsing MS Treated With Ozanimod (RPC-1063)

    A study to determine if oral ozanimod can affect cognitive processing speed in people with relapsing MS. All subjects will receive orally administered ozanimod HCl 1 mg. 
  8. Research Study: Physiologic dysfunction in MS-related Fatigue

    This research study is designed to assess whether physiologic dysfunction contributes to fatigue in people with MS. This connection will help guide routine neurological treatment fatigue in MS in the future.  Physiologic testing includes measurement of a person’s pupil functi...
  9. Clinical Trial: Evobrutinib vs. teriflunomide in Relapsing MS

    Investigators in the U.S. and abroad are recruiting a total of 1860 people with relapsing forms of MS for two separate studies comparing investigational oral evobrutinib with Aubagio® (teriflunomide, Sanofi Genzyme). Read more
  10. Clinical Trial: BIIB017 (peginterferon beta-1a) in children and teens with MS

    This study aims to evaluate the safety, tolerability, and effectiveness of BIIB017 for the treatment of children and teens ages 10 to less than 18 with relapsing-remitting MS. Participants will take BIIB017 (peginterferon beta-1a) or Avonex (interferon beta-1a). Participation ...
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