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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19


Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Reducing Fatigue and Restoring Energy to Support Health (REFRESH)

    Description SUMMARY: A new research study is testing the effectiveness of an educational program that is delivered over the phone, internet, or videoconference.  Participating in the study will involve one assessment by videoconference , filling out 4 questionnaires over a...
  2. Clinical Trial: Sensory Stimulation for Neuromuscular Function and Balance in MS

      The purpose of this study is to investigate the influence of transcutaneous electrical nerve stimulation ( TENS ) on standing balance, strength, and force control in individuals with multiple sclerosis (MS). The project will include two evaluation sessions (visits) (appr...
  3. Clinical Trial: Low load resistance training using blood flow restriction for MS

    This research study proposes to investigate a strengthening program along with blood flow restriction to improve strength and mobility in people with multiple sclerosis who have walking limitations. The study will include 20 people with MS who need at least a cane to walk 100 ...
  4. Clinical Trial: ReCOVER – Clemastine Fumarate in Optic Neuritis

    WE ARE ACTIVELY RECRUITING PEOPLE EXPERIENCING A SUSPECTED OR DIAGNOSED ACUTE OPTIC NEURITIS IN A PREVIOUSLY UNAFFECTED EYE. VISUAL SYMPTOMS MUST BE WITHIN THE PAST 3 WEEKS AND THE PATIENT MUST BE STEROID NAIVE.  ReCOVER aims to assess the effect of Clemastine Fumarate as a...
  5. Clinical Trial: Higher dose of ocrelizumab in PPMS

    An open-label, single-arm study to evaluate the effectiveness and safety of ocrelizumab in people with primary progressive MS. Subjects participating in the study will complete the following procedures: study visits, blood draw/sample collections, MRI Scans, potential lumbar p...
  6. Clinical Trial: Higher dose of ocrelizumab in PPMS

    An open-label, single-arm study to evaluate the effectiveness and safety of ocrelizumab in people with primary progressive MS. Subjects participating in the study will complete the following procedures: study visits, blood draw/sample collections, MRI Scans, potential lumbar p...
  7. Clinical Trial: Evaluating Mobility Interventions in the Real World

    What is this study about? We want to study the best ways to help people walk and run better using lower-limb orthoses (leg braces). To do this, we will study people who use orthoses, as well as people who don’t. What will happen during the study? You might do an...
  8. Clinical Trial: Impact of cold compression on fatigue, pain and functional performance in MS

    Heat sensitivity is a common negative condition in people with Multiple Sclerosis and physical fatigue is one of the most frequently reported symptoms that can affect quality of life. Increases in body temperature may make fatigue and heat-related symptoms worse. Decreasing bo...
  9. Clinical Trial: Nabiximols Oromucosal Spray as Add-on Therapy in People With Spasticity Due to MS

    Accellacare is now enrolling men or women, age 18+, to participate in a research study in Winston-Salem, North Carolina. Participants must have been diagnosed with multiple sclerosis for at least 12 months. Participants also should be currently receiving optimized treatment wi...
  10. Clinical Trial: IMS001 in people with MS

    The purpose of this research is to determine the safety, tolerability, efficacy, and optimal dose regimen of an investigational human embryonic stem cell derived (hESC) mesenchymal stem cell (MSC) product to treat MS called IMS001.Taking part in this research will last for up ...
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