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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Intranasal Insulin for Improving Cognitive Function

    This is a randomized, double-blind, placebo-controlled study in people with MS. This study will evaluate if giving insulin that is administered in the nostrils (intranasal) is safe and tolerable for people with MS. It is also being done to evaluate if intranasal insulin improv...
  2. Clinical Trial: Measurement and Training of Dual-Task of Gait

    TIRR Memorial Hermann and Texas Woman's University are currently recruiting for a rehabilitation-based study measuring dual-task of gait in people with MS and comparing the effectiveness of a specific dual-task gait intervention in improving the walking performance of people w...
  3. Clinical Trial: Oral Ponesimod Added to Tecfidera

    Investigators are recruiting 600 people with relapsing MS for a clinical trial examining the effectiveness of adding ponesimod, an oral compound that affects immune function, in people who are still experiencing relapses while taking Tecfidera ® (dimethyl fumarate, Biogen, In...
  4. Clinical Trial: A COOL-MS Pilot Study

    Two of the most commonly reported symptoms of multiple sclerosis are fatigue and sensitivity to heat. Additionally, persons with multiple sclerosis (PwMS) often have greater difficulty performing cognitive and motor tasks simultaneously (i.e. walking and talking), presenting a...
  5. Clinical Trial: Acute Intermittent Hypoxia

    Acute intermittent hypoxia is a breathing intervention that alternates brief bouts of breathing low and normal levels of oxygen. This treatment has successfully improved motor function in other populations with lower limb mobility difficulties, but has never been used in MS co...
  6. Amantidine for Walking Impairment

    A 3-Arm, Multicenter, Double-Blind, Placebo-Controlled, Randomized Study to Assess the Efficacy and Safety of ADS-5102 Amantidine Extended Release Capsule in People with Multiple and Walking Impairment.
  7. Clinical Trial: Ofatumumab

    12-week study for treatment of Relapsing MS, followed by a 4.5-year extension study. Qualifying participants will receive study medication and study related exams at no cost. Compensation will be provided for time and travel costs.  To qualify: Must be between 18-55 year...
  8. Clinical Trial: ADS-5102 (amantadine extended release [ER] capsules)

    The INROADS study is now enrolling volunteers to help test an investigational study drug for people with MS who have trouble walking. Researchers want to learn if the investigational medication may help improve walking and become a future treatment option. If you qualify and ...
  9. Clinical Trial: Biomarker-Guided Combination Therapies for MS

    In people with MS, brain and cerebrospinal fluid biomarkers indicate inflammation or disease. Researchers at the National Institutes Health (NIH) seek volunteers with MS to see if 4 therapies given alone or combined affect MS biomarkers. They want to see if a change in biomark...
  10. Clinical Trial: ReCOVER – Clemastine Fumarate in Optic Neuritis

    WE ARE ACTIVELY RECRUITING PEOPLE EXPERIENCING A SUSPECTED OR DIAGNOSED ACUTE OPTIC NEURITIS IN AN EYE NOT PREVIOUSLY AFFECTED AND HAS YET TO RECEIVE STEROID TREATMENT FOR.    ReCOVER aims to assess the effect of clemastine as a myelin repair agent and its potential for th...
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