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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Reducing Fatigue and Restoring Energy to Support Health

    SUMMARY: A new research study is testing the effectiveness of an educational program that is delivered over the phone, internet, or in-person.  Participating in the study will involve one in-person assessment (held in your local community), filling out 4 questionnaires over a ...
  2. Clinical Trial: Siponimod in MS

    To assess early phase safety and tolerability of converting from approved oral and injectable disease-modifying therapies for relapsing MS to siponimod. The results of this study will guide clinically relevant decisions related to the transition from frequently used therapies ...
  3. Clinical Trial: Hypnosis for Fatigue Management, English and Spanish

    Fatigue is a common, disabling, and debilitating symptom in individuals with MS. Research has shown that psychological treatments can help people with fatigue management and improve their quality of life. A common psychological treatment for fatigue is hypnosis. There are two ...
  4. Clinical Trial: Development of a Telehealth Obesity Intervention for People with MS

    This study is a behavioral telehealth program to help patients with MS who want to lose weight and live a healthier lifestyle.  Participants in this study will receive 24 weekly group phone counseling sessions. Each session will last approximately 60 minutes. In addition to...
  5. Research Study: Assessment of Portable Magnetic Resonance Imaging

    This study aims to examine the use of a novel portable MRI machine, which has been developed by physicists and physicians at the Massachusetts General Hospital. The MRI machine uses permanent magnets, meaning it doesn’t need liquid helium coolant, makes significantly less sou...
  6. Clinical Trial: Malignancies and MS Treatment

    VERISMO is a long-term, observational safety study of patients who are newly starting Ocrevus, or Lemtrada, Mavenclad, Tecfidera, Gilenya, Tysabri, or Aubagio. The goal of the study is to determine the full safety profile of Ocrevus compared to these other MS DMTs (disease mod...
  7. Clinical Trial: Cognitive Processing Speed Changes in Relapsing MS Treated With Ozanimod (RPC-1063)

    A study to determine if oral ozanimod can affect cognitive processing speed in people with relapsing MS. All subjects will receive orally administered ozanimod HCl 1 mg.  Please note: In response to the recent developments of the COVID-19 pandemic, sites are implementing me...
  8. Clinical Trial: GA Depot in Relapsing MS

    A multinational, multicenter, randomized, Phase III, double blind, parallel group, placebo controlled study in subjects with Relapsing Forms of Multiple Sclerosis to assess the efficacy, safety and tolerability of GA Depot, a long acting injection of glatiramer acetate into mu...
  9. Clinical Trial: ATA188 in Progressive MS

    Investigators are recruiting  up to 72 people with primary progressive or secondary progressive MS from six sites across the United States (Louisiana, North Carolina, Pennsylvania, Tennessee, Texas, Washington) and in Australia for a phase 1b clinical trial of the investigatio...
  10. Clinical Trial: Evobrutinib in Relapsing MS

    Participation could last for up to 2 years and 4 months, with up to 26 study visits.  Evobrutinib will be compared to teriflunomide, a medication that is already used to treat RMS.  Participants will have an equal chance of receiving either the investigational medication or ...
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