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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS

The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email to find out what information you need to submit for review.


Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Exploratory Study of Entire-body PET Scans for Multiple Sclerosis

    Can an entire-body positron emission tomography (PET) scanner be used to improve evaluation, monitoring and measurement of both peripheral and central damage to nerve-insulating myelin (demyelination) in people with MS? We assume here that demyelination outside the brain may i...
  2. Clinical Trial Name: High-Intensity, Dynamic-stability Gait Training in People With MS

    This study is being conducted to understand whether high intensity exercise and disturbances to balance can be used to improve walking and balance. Individuals that enroll in this study will be randomly assigned to one of four treadmill training groups. One group will conduct ...
  3. Clinical Trial: Fenebrutinib

    A study to evaluate the effectiveness and safety of fenebrutinib on disability progression and relapse rate. Eligible participants will be randomly assigned to receive either fenebrutinib or teriflunomide. Some may then  receive fenebrutinib during an open label extension.
  4. Clinical Trial: Gait training to improve walking

    Over 90% of persons with MS complain of difficulty with walking. High intensity interval gait training, where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve walking in other neurologic diagnoses. However, its impact on ...
  5. Clinical Trial: Home-Based Exercise Program for African Americans with MS (TEAAMS)

    The goal of the TEAAMS study is to examine whether a home-based exercise training program can provide improvements in walking dysfunction, symptoms, and quality of life among Black and African Americans with MS who live in the Southern US. Participants will exercise at their c...
  6. Clinical Trial: Impact of Vancomycin on the Gut Microbiome and Immune Function in MS

    The goal of this study is to see if changes in the gut microbiome can alter multiple sclerosis outcomes.  Participants are newly diagnosed with MS (symptoms onset lest than 6 months) who have never taken disease-modifying treatment.  Participants will take vancomycin, an antib...
  7. Clinical Trial: Improving New Learning and Memory in MS

    The Kessler Foundation is currently recruiting for a study on memory. Participants will be compensated.. The study involves paper-and-pencil testing and is intended to assess the efficacy of learning and memory techniques within the Multiple Sclerosis population. Additionally,...
  8. Clinical Trial: IMS001 in people with MS

    The purpose of this research is to determine the safety, tolerability, efficacy, and optimal dose regimen of an investigational human embryonic stem cell derived (hESC) mesenchymal stem cell (MSC) product to treat MS called IMS001.Taking part in this research will last for up ...
  9. Clinical Trial: IMU-838 in Adults with Progressive MS

    This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate efficacy, safety, and tolerability of IMU-838 in people between 18 and 65 years old with primary or secondary progressive multiple sclerosis. Participants will be randomly assigned to receive...
  10. Clinical Trial: IMU-838 versus Placebo in Adults with Relapsing MS

    These are two multi-center, randomized, double-blinded phase 3 studies to evaluate the efficacy, safety, and tolerability of IMU-838 versus placebo in adults (male or female between 18 and 55 years old) with relapsing multiple sclerosis (also called ENSURE-1 and ENSURE-2). Eac...
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