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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Effects of Opal Cool Wrap on Symptoms and Quality of Life in Women with MS

    Study Title: Effects of Opal Cool Wrap on Symptoms and Quality of Life in Women with Multiple Sclerosis   Researchers at St. Catherine University are seeking women participants with multiple sclerosis (MS) to determine the effectiveness of the Opal Cool Wrap (an external...
  2. Clinical Trial: SleepWell! with MS

    Disrupted sleep is common among adults with MS. A new iPhone/iPad app (SleepWell! with MS) has been developed that will allow adults with MS to access mindfulness and sleep education from their own personal Apple devices. During this study, participants will practice meditatio...
  3. Clinical Trial: Robotic exoskeleton

    The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton (RE) device, called Ekso-GT, to improve learning, memory and walking ability in persons with walking disability due to Multiple Sclerosis. The study will evaluate the mobility, l...
  4. Clinical Trial: Spasticity Management Program

    Participation online via video conferencing is now available. Participants will be placed randomly into one of two groups and will receive one of two different spasticity management exercise programs. Each program consists of education and exercise training intended to help re...
  5. Clinical Trial: Fenebrutinib

    A study to evaluate the effectiveness and safety of fenebrutinib on disability progression and relapse rate. Eligible participants will be randomly assigned to receive either fenebrutinib or teriflunomide. Some may then  receive fenebrutinib during an open label extension.
  6. Clinical Trial: Ocrelizumab

    This is a double blind, multicenter study to evaluate the effectiveness, safety and pharmacokinetics (how the drug moves within the body) of a higher dose of ocrelizumab taken via intravenous infusion every 24 weeks in people with relapsing MS, in comparison to the approved 60...
  7. Clinical Trial: Comparing Experimental Fenebrutinib to Ocrevus® in Primary Progressive MS

    Investigators in the U.S. and abroad are recruiting 946 people with primary progressive MS for a study comparing investigational oral fenebrutinib with  Ocrevus ®  (ocrelizumab - Genentech, a member of the Roche Group). The study – also called FENtrepid – is sponsored by F. H...
  8. Clinical Trial: Estriol

    A double-blind, placebo controlled trial to determine whether estriol treatment (added on to standard therapies) improves cognition in women with multiple sclerosis.
  9. Clinical Trial: Ozanimod for Cognitive Function

    This is a multicenter, single-arm, open-label study to describe the change from baseline in cognitive processing speed in subjects with relapsing multiple sclerosis (RMS) treated with ozanimod HCl 1 mg at 3 years. All enrolled subjects will receive orally administered ozanimod...
  10. Clinical Trial: Lipoic acid for Treatment of Progressive Multiple Sclerosis (LAPMS)

    Dr. Rebecca Spain, a neurologist at the VA Portland Health Care System, is conducting a multicenter study to see if the over the counter antioxidant, lipoic acid, helps multiple sclerosis (MS) and is safe to take in people with progressive forms of MS. They are looking for in...
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