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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Research Study: Seeking first degree relatives of people with MS for study of risk factors

    The goal of this study is to learn more about the causes of and risk factors for MS by studying first-degree relatives of people with MS and comparing them to people who are not first-degree relatives of someone with MS. We will use the data collected to develop a risk algorit...
  2. Clinical Trial: Emotion Regulation Skills Training

    Researchers are conducting a research study to help people with multiple sclerosis (MS) and their support partners learn skills for reducing symptoms of depression and anxiety and improving quality of life. Support partners can include significant others, friends, and family m...
  3. Clinical Trial: Oral Siponimod

    To assess early phase safety and tolerability of converting from approved oral and injectable disease-modifying therapies for relapsing MS to siponimod. The results of this study will guide clinically relevant decisions related to the transition from frequently used therapies ...
  4. Clinical Trial: Electronic Pill Bottle

    People with MS have variable adherence to MS medications, making it challenging to determine the effectiveness of disease modifying therapies to assess true treatment failures. Whereas some people forget to take medications due to active lifestyles, others may have cognitive i...
  5. Clinical Trial: autologous hematopoietic stem cell transplantation (AHSCT)

    Investigators are recruiting 156 people with relapsing MS (relapsing-remitting MS or secondary progressive MS with relapses) at 19 sites nationwide for a pivotal clinical trial comparing autologous hematopoietic stem cell transplantation (AHSCT, also commonly known as HSCT) to...
  6. Clinical Trial: Physical Activity Class – Online Program

    Dr. Chung-Yi Chiu at the University of Illinois is conducting a study on lifestyle changes to increase physical activity levels for people with multiple sclerosis.   This 8 week program is led by peer coaches with MS who are experienced in a physically active lifestyle. Th...
  7. Clinical Trial: Computerized Cognitive Training

    The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for people with MS. Participants would complete a set of tests (physical an...
  8. Clinical Trial: Virtual Reality Treadmill Training for MS

    This study is testing whether a 6 week virtual reality treadmill exercise program with a trained therapist improves mobility and cognitive function.  Compensation is provided.  Available for individuals diagnosed with relapsing remitting MS and between ages of 18 and 65.   ...
  9. Clinical Trial: Multifaceted Fall Prevention Program for People with MS who Use Wheelchairs or Scooters

    The purpose of the proposed study is to examine the effectiveness of a community-based rehabilitation educational intervention on management of falls in non-ambulatory individuals with MS (Multifaceted Fall Prevention Program). Programs that target both physiological and behav...
  10. Clinical Trial: Mindfulness-based intervention to relieve symptoms

    The purpose of this research study is to test the effects of a nurse-inspired, web-based mindfulness based expressive art therapy in persons with MS. To qualify, signed informed consent is needed, along with collection of saliva for cytokine and body temperature. The web-based...
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