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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: UCSF MS and COVID-19 Immunity Study

    MS treatment involves the use of medications that target the immune system, which can increase the risk of certain infections.  This study is being conducted to get a better understanding of how immunity to COVID-19 vaccination may be impacted by MS treatments.   Criteria fo...
  2. Clinical Trial: Immune responses to COVID vaccines in people with MS on ocrelizumab

    It is not know whether people receiving ocrelizumab for MS mount adequate immune responses to COVID-19 vaccine. The study is designed to investigate B-cell and T-cell responses to COVID-19 vaccination in patients treated with Ocrevus.  There are 5 visits for this study. All...
  3. Clinical Trial: autologous hematopoietic stem cell transplantation (AHSCT)

    Investigators are recruiting 156 people with relapsing MS (relapsing-remitting MS or secondary progressive MS with relapses) at 19 sites nationwide for a pivotal clinical trial comparing autologous hematopoietic stem cell transplantation (AHSCT, also commonly known as HSCT) to...
  4. Clinical Trial: Ocrelizumab in Progressive MS (CONSONANCE)

    The purpose of the study is to see if Ocrelizumab will halt the worsening of the signs and symptoms of Progressive forms of MS. Smartphone-based “passive monitoring” of participants will also take place during the study. It will collect data on gait and mobility throughout the...
  5. Clinical Trial: Ofatumumab for Patients with Relapsing Multiple Sclerosis

    MS study evaluating the continued effectiveness, safety and tolerability of Ofatumumab in adults, between the ages 18-60, with relapsing multiple sclerosis who are transitioning from traditional anti-CD20 therapy. Click on this link to answer a few questions to see if you q...
  6. Clinical Trial: Ocrelizumab in Black Americans and Hispanic/Latinx with Relapsing MS

    Investigators are recruiting 150 Black Americans and Hispanic/Latinx with relapsing MS to determine the effectiveness of  Ocrevus ®  (ocrelizumab) in these groups. The study, sponsored by Genentech, Inc., also is known as the CHIMES study. Read more
  7. Clinical Trial: ATOMIC Physical Activity Research Program for Teens with MS

    Youth with MS are commonly physically inactive. Vigorous physical activity has shown to improve well-being while lowering MS disease activity in youth. There is currently a lack of useful physical activity tools developed for youth with MS. With the input of youth with MS, thi...
  8. Clinical Trial: Antioxidant for fatigue in MS

    This clinical trial will evaluate the potential beneficial effects of Mitoquinone (MitoQ), an antioxidant, on MS fatigue. It will also explore the effects of MitoQ on cognitive function, quality of life and mood. Participants are adults between the ages of 18 and 70 diagnosed ...
  9. Clinical Trial: Ozanimod for Cognitive Function

    This is a multicenter, single-arm, open-label study to describe the change from baseline in cognitive processing speed in subjects with relapsing multiple sclerosis (RMS) treated with ozanimod HCl 1 mg at 3 years. All enrolled subjects will receive orally administered ozanimod...
  10. Clinical Trial: Ozanimod to Improve Cognitive Function

     Investigators are recruiting 250 people with relapsing forms of MS for a clinical trial to determine if ozanimod (Zeposia ® , Bristol Myers Squibb) improves cognitive functions, specifically information processing speed. The study is funded by Celgene. Read more
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