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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Research Study: Mechanisms of Low Physical Work Capacity, Fatigue, and Reduced Mobility

    You are being asked to be a subject in a research study about blood flow regulation during exercise and how that may affect work capacity (the ability to perform exercise). This study will examine cardiac output (how much blood your heart can pump each minute) during a treadmi...
  2. Clinical Trial: Lutein and Multiple Sclerosis Experimental Study (LuMES)

    The Body Composition and Nutritional Neuroscience lab at the University of Illinois at Urbana-Champaign is recruiting adults between 18-64 years with Multiple Sclerosis for a study that investigates the importance of nutrition for eye health and thinking ability among persons ...
  3. Clinical Trials: Transcranial Direct Current Stimulation Studies

    Researchers at New York University are recruiting people with MS for three studies involving transcranial direct current stimulation (tDCS, which involves low electrical current delivered via electrodes). Clinical Trial: Neuroimaging with Transcranial Direct Current Stimulat...
  4. Clinical Trial: Comparing Experimental Tolebrutinib with Placebo in Progressive MS

    SUMMARY: Investigators in the U.S. and abroad are recruiting a total of 2280 people with progressive forms of MS for two separate studies comparing investigational oral tolebrutinib with placebo. The studies – also called HERCULES and PERSEUS – are sponsored by Sanofi .   ...
  5. Clinical Trial: Comparing Experimental Tolebrutinib with Aubagio® in Relapsing MS

    SUMMARY: Investigators are recruiting a total of 1800 people with relapsing forms of MS worldwide for two studies comparing investigational oral tolebrutinib with Aubagio ®  (teriflunomide, Sanofi Genzyme). The studies – also called GEMINI 1 and GEMINI 2 – are sponsored by San...
  6. Clinical Trial: Effect of Disease Modifying Therapy on Antibody Response to COVID-19 Vaccination in People with MS

    The objective of the study is to determine whether certain disease modifying therapies impair or shorten immune responses to COVID-19 vaccines. The researchers are measuring antibody levels following vaccination with Moderna mRNA-1273 vaccine in people with MS. Therapies under...
  7. Clinical Trial: ASPIRE (Aspirin for Exercise in Multiple Sclerosis)

    ASPIRE is a clinical trial to investigate aspirin as a treatment to improve exercise performance in people with MS who experience overheating during exercise.
  8. Clinical Trial: UCSF MS and COVID-19 Immunity Study

    MS treatment involves the use of medications that target the immune system, which can increase the risk of certain infections.  This study is being conducted to get a better understanding of how immunity to COVID-19 vaccination may be impacted by MS treatments.   Criteria fo...
  9. Clinical Trial: Immune responses to COVID vaccines in people with MS on ocrelizumab

    It is not know whether people receiving ocrelizumab for MS mount adequate immune responses to COVID-19 vaccine. The study is designed to investigate B-cell and T-cell responses to COVID-19 vaccination in patients treated with Ocrevus.  There are 5 visits for this study. All...
  10. Clinical Trial: Comparing Experimental Fenebrutinib to Aubagio® in Relapsing MS

     Investigators in the U.S. and abroad are recruiting a total of 1468 people with relapsing forms of MS for two separate studies comparing investigational oral fenebrutinib with Aubagio ® (teriflunomide, Sanofi Genzyme). The studies – also called FENhance – are sponsored by F....
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