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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Evobrutinib in Relapsing MS

    The study is to evaluate the efficacy and safety of Evobrutinib administered orally twice daily versus Teriflunomide (Aubagio®), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS). Please note: In response to the recent developments of th...

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  2. Clinical Trial: Evobrutinib in Relapsing MS

    The purpose of this study is to characterize the efficacy and safety of evobrutinib 45 mg administered orally twice daily versus teriflunomide (Aubagio®; 14 mg once a day orally) in participants with relapsing multiple sclerosis (RMS) or Secondary Progressive multiple sclerosi...

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  3. Clinical Trial: Phase III Study of Evobrutinib in RMS

    The purpose of this study is to characterize the efficacy and safety of evobrutinib 45 mg administered orally twice daily versus teriflunomide (Aubagio®; 14 mg once a day orally) in participants with relapsing multiple sclerosis (RMS).  Contact Name:  Goher Haneef or Sh...

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  4. Research Study: The Sutter Health MS genetic study

    The Sutter Health MS genetic study is recruiting people with MS from ten sites to participate in a DNA sequencing study. The main objectives are to identify biomarkers of disease subtype, progression, and treatment response. The study is open to current and new Sutter Health p...

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  5. Clinical Trial: ReWRAP: Remyelination for Women at Risk for Axonal Loss and Progression

    Dr. Riley Bove and her colleagues at the UCSF Multiple Sclerosis center are conducting a clinical trial to assess the efficacy of bazedoxifene (BZA) in promoting the repair of myelin (remyelination), an important insulating layer for neurons in the central nervous system a...

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  6. Clinical Trial: SAR442168

    This is a Phase 3, randomized, double-blind, 2-arm, placebo-controlled, parallel-group, multicenter, trial to determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis

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  7. Clinical Trial: SAR442168

     A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with nonrelapsing secondary progressive multiple sclerosis (HERCULES)  

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  8. Research Study: Fatigue

    Please note: This is not a clinical trial of an intervention, but rather a research study.  The purpose of this study is to systematically evaluate the relationship between fatigue severity, autonomic (involuntary) symptom burden, and autonomic physiological markers in MS p...

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  9. Clinical Trial: Evobrutinib in Relapsing MS

    The purpose of this study is to characterize the efficacy and safety of evobrutinib 45 mg administered orally twice daily versus teriflunomide (Aubagio®; 14 mg once a day orally) in participants with relapsing multiple sclerosis (RMS).  

    Get Details

  10. Clinical Trial: ASPIRE (Aspirin for Exercise in Multiple Sclerosis)

    ASPIRE is a clinical trial to investigate aspirin as a treatment to improve exercise performance in people with MS who experience overheating during exercise.

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