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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS

The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email to find out what information you need to submit for review.


NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Electronic Pill Bottle

    People with MS have variable adherence to MS medications, making it challenging to determine the effectiveness of disease modifying therapies to assess true treatment failures. Whereas some people forget to take medications due to active lifestyles, others may have cognitive i...
  2. Research Study: Assessment of Portable Magnetic Resonance Imaging

    This study aims to examine the use of a novel portable MRI machine, which has been developed by physicists and physicians at the Massachusetts General Hospital. The MRI machine uses permanent magnets, meaning it doesn’t need liquid helium coolant, makes significantly less sou...
  3. Clinical Trial: Malignancies and MS Treatment

    VERISMO is a long-term, observational safety study of patients who are newly starting Ocrevus, or Lemtrada, Mavenclad, Tecfidera, Gilenya, Tysabri, or Aubagio. The goal of the study is to determine the full safety profile of Ocrevus compared to these other MS DMTs (disease mod...
  4. Clinical Trial: Cognitive Processing Speed Changes in Relapsing MS Treated With Ozanimod (RPC-1063)

    A study to determine if oral ozanimod can affect cognitive processing speed in people with relapsing MS. All subjects will receive orally administered ozanimod HCl 1 mg.  Please note: In response to the recent developments of the COVID-19 pandemic, sites are implementing me...
  5. Clinical Trial: Cognitive Behavioral Therapy, Modafinil, or Both for MS Fatigue ("COMBO-MS")

    Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect.  This clinical trial will compare the effectivenes...
  6. Clinical Trial: GA Depot in Relapsing MS

    A multinational, multicenter, randomized, Phase III, double blind, parallel group, placebo controlled study in subjects with Relapsing Forms of Multiple Sclerosis to assess the efficacy, safety and tolerability of GA Depot, a long acting injection of glatiramer acetate into mu...
  7. Clinical Trial: ATA188 in Progressive MS

    Investigators are recruiting  up to 72 people with primary progressive or secondary progressive MS from six sites across the United States (Louisiana, North Carolina, Pennsylvania, Tennessee, Texas, Washington) and in Australia for a phase 1b clinical trial of the investigatio...
  8. Clinical Trial: Evobrutinib in Relapsing MS

    Participation could last for up to 2 years and 4 months, with up to 26 study visits.  Evobrutinib will be compared to teriflunomide, a medication that is already used to treat RMS.  Participants will have an equal chance of receiving either the investigational medication or ...
  9. Clinical Trial: Evobrutinib in Relapsing MS

    The study is to evaluate the efficacy and safety of Evobrutinib administered orally twice daily versus Teriflunomide (Aubagio®), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS). Please note: In response to the recent developments of th...
  10. Clinical Trial: Evobrutinib in Relapsing MS

    The purpose of this study is to characterize the efficacy and safety of evobrutinib 45 mg administered orally twice daily versus teriflunomide (Aubagio®; 14 mg once a day orally) in participants with relapsing multiple sclerosis (RMS) or Secondary Progressive multiple sclerosi...
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