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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

    This study will evaluate the effectiveness and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS), including participants later in their disease course. This study focuses on upper limit disability progres...

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  2. Clinical Trial: Increasing Physical Activity for Restless Legs Syndrome in Adults with MS

    This study is evaluating a 16 week internet-delivered program for increasing physical activity in adults with MS who have restless legs syndrome (RLS). Participants will attend two sessions at the lab; one before the program and one after the end of the program. Ultimately, th...

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  3. Clinical Trial: Skeletal Muscle Blood Flow During Exercise in Persons with MS

    Previous studies have shown that people with MS may have impaired blood pressure and heart rate responses to standard tests. The systems that regulate heart rate and blood pressure responses are important to properly distribute blood flow to active muscle during exercise or ph...

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  4. Research Study: looking at causes of fatiguing illness including MS

    This is an observational study looking at a symptomatic, immune function and inflammatory markers of disease with respect to fatiguing illnesses and their potential causes.  Participants will be asked to fill out a set of questionnaires, contribute saliva and blood, and have a...

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  5. Research Study: International MS Microbiome Study

    This study aims to understand the role of gut bacteria in MS, and by extension allows us to look at the effects of diet and environment on the gut microbiome and MS disease susceptibility and progression. For this study, we are asking that participants donate blood and stool ...

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  6. Research Study: health behavior and wellness outcomes with wheelchair use

    Very little is known about health behaviors and the impact on symptoms in adults with MS who use wheelchairs. The Exercise Neuroscience Research Laboratory at the University of Alabama, Birmingham invites you to participate in a voluntary study of health behaviors in adults wi...

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  7. Research Study: Pediatric RRMS

    Researchers are asking teens with MS and their siblings without MS between the ages of 12-18 to participate in an observational study.  With an MRI using a stronger magnet, a specialized picture of the brain, researchers at UTSW might predict an if an individual may have diffi...

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  8. Clinical Trial: Cognitive Behavioral Therapy, Modafinil, or Both for MS Fatigue ("COMBO-MS")

    Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect.  This clinical trial will compare the effectivenes...

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  9. Clinical Trial: Coping and Adjusting to Living with MS (CALMS) Study

    This study, Coping and Adjusting to Living with Multiple Sclerosis or CALMS, is looking at whether a telephone-based wellness program, called Cognitive Behavioral Therapy for Uncertainty Tolerance in Multiple Sclerosis (MS), is helpful for adults over the age of 18 who are exp...

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  10. Clinical Trial: Lipoic acid for Treatment of Progressive Multiple Sclerosis (LAPMS)

    Dr. Rebecca Spain, a neurologist at the VA Portland Health Care System, is conducting a multicenter study to see if the over the counter antioxidant, lipoic acid, helps multiple sclerosis (MS) and is safe to take in people with progressive forms of MS. They are looking for in...

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