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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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NOTE: The COVID-19 pandemic may affect the status of the studies listed on this website. Trial recruitment or visits may be postponed, and responses from study coordinators may be delayed. If you are enrolled in a study, your study coordinator will likely reach out to you with any changes. Learn what you need to know about COVID-19

Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: STEP for MS, an Exercise Intervention

    New research shows that exercise is good for people with MS and may decrease symptoms and improve health and walking ability. An exercise study called STEP for MS will compare the outcomes of a 16-week exercise program conducted at home to a program conducted in a gym. A train...

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  2. Clinical Trial: Ofatumumab

    A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patient- reported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy. FDA Approved medication (Brand na...

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  3. Clinical Trial: Probiotic for Urinary Symptoms Among People Who Use Catheters

    Researchers at MedStar National Rehabilitation Hospital are recruiting people who use indwelling or intermittent catheters for a two-part study. In the first part, investigators are taking 2 urine samples collected at least 2 weeks apart, and administering questionnaires about...

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  4. Clinical Trial: Home Based Tele-exercise for People With Chronic Neurological Impairments

    This study is assessing the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI). The seated exercise study will include: • Adaptive Boxing • Adaptive Power Posture • Adapt...

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  5. Clinical Trial: Physical Therapy to Prevent or Reduce Falls

    Dr. Michelle Cameron, a neurologist at OHSU and at the VA Portland Health Care System, is recruiting for the ADSTEP research study, which explores whether a training program on improving walking aid use can prevent and reduce falls in people with MS who use a walking aid. ...

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  6. Clinical Trial: Cognitive Behavioral Therapy, Modafinil, or Both for MS Fatigue ("COMBO-MS")

    Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect.  This clinical trial will compare the effectivenes...

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  7. Clinical Trial: MBCT and CBT for Chronic Pain in Multiple Sclerosis

    Chronic pain is a disabling and persistent symptom associated with MS, and it has been linked with poorer health, depression, sleep disruption, inactivity, and problems with work and social life. Currently, drugs used to treat pain rarely provide complete relief and often invo...

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  8. Clinical Trial: Spasticity Management Program

    Participation online via video conferencing is now available. Participants will be placed randomly into one of two groups and will receive one of two different spasticity management exercise programs. Each program consists of education and exercise training intended to help re...

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  9. Clinical Trial: Comparing Experimental Tolebrutinib with Aubagio® in Relapsing MS

    SUMMARY: Investigators are recruiting a total of 1800 people with relapsing forms of MS worldwide for two studies comparing investigational oral tolebrutinib with Aubagio ®  (teriflunomide, Sanofi Genzyme). The studies – also called GEMINI 1 and GEMINI 2 – are sponsored by San...

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  10. Clinical Trial: Online Gentle Movement and Education for Pairs with Chronic Pain

    Researchers are looking for two connected people (spouses, partners, parent/adult child, and friends/neighbors) who have chronic pain and who help each other to take part in an online/virtual education and gentle movement study. Participants with the following criteria: ✓...

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Learn About Clinical Trials

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