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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trial: Physical Training and Endurance Testing of Manual Wheelchair Users

    The Program in Occupational Therapy at Washington University School of Medicine in St. Louis is conducting research to test a developed endurance exercise intervention program to determine if such a program can positively impact the physical, metabolic, and psychosocial fitnes...
  2. Clinical Trial: Wheelchair propulsion training program

    The Program in Occupational Therapy at Washington University School of Medicine in St. Louis is conducting research to develop, implement, and test manual  wheelchair propulsion training for manual wheelchair users. The participants will be involved in the study approximatel...
  3. Clinical Trial: My MS Toolkit

    Researchers at University of Michigan are leading this study aimed at improving self-management of pain, fatigue, and depressed mood through a web-based program. Participants enrolled in this study will use a newly developed web-based symptom self-management program called the...
  4. Clinical Trial: Comparing the Effectiveness of Fatigue Management Programs for People with MS

    Participants will engage in a six-week program taught by clinical experts (occupational therapists) over the phone, internet, or in-person. Participants may learn strategies that will empower them to reduce fatigue and reduce the impact of fatigue on quality of life. Please...
  5. Clinical Trial: Web-based Cognitive Behavioral Therapy for Insomnia

    Insomnia is a prevalent issue in people with MS, and the best method to treat insomnia in people with MS remains unknown. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to be an effective treatment in individuals with insomnia. However, there are limited numb...
  6. Clinical Trial: STEP for MS, an Exercise Intervention

    This study aims to compare the effectiveness of an exercise program delivered in a conventional facility-based format versus a telerehabilitation format, which takes place in the home. Exercise can improve mobility and perhaps decrease the rate and extent of disability in peop...
  7. Clinical Trial: Siponimod in advancing forms of relapsing MS

    Exploring the safety and tolerability of conversion from oral or injectable disease modifying therapies to dose-titrated Oral Siponimod in patients with advancing forms of relapsing multiple sclerosis. You, or someone you care for, may be able to take part if you/they: • are...
  8. Research Study: Physiologic dysfunction in MS-related Fatigue

    This research study is designed to assess whether physiologic dysfunction contributes to fatigue in people with MS. This connection will help guide routine neurological treatment fatigue in MS in the future.  Physiologic testing includes measurement of a person’s pupil functi...
  9. Clinical Trial: Oral Ponesimod Added to Tecfidera

    Investigators are recruiting people with relapsing MS for a clinical trial examining the effectiveness of adding ponesimod, an oral compound that affects immune function, in people who are still experiencing relapses while taking Tecfidera ®  (dimethyl fumarate, Biogen, Inc.).
  10. Online Survey: Healthcare Providers Sought for Survey on Exercise Promotion

    Researchers Funded by the National MS Society Seeking Healthcare Providers to Complete Survey on Exercise Promotion   Researchers at the Exercise Neuroscience Research Lab (ENRL), University of Alabama at Birmingham are developing a line of research to improve exercise p...
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