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Participate in a Clinical Trial

Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.

Clinical Trials in MS


The latest clinical research in MS, including trials funded by the Society and trials in progressive MS.

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Posting a Trial

If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.

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Clinical trials help to determine if treatments are safe and effective. Studies are monitored to ensure that the rights and safety of all participants are protected. Make an informed decision before agreeing to participate. Read more in our Guide to Participating in Clinical Trials.

Clinical Trials In Your Area

Interested in clinical trials? Simply search by state, type of MS or keyword and see what’s going on in your area.

  1. Clinical Trials: Transcranial Direct Current Stimulation Studies

    Researchers at New York University are recruiting people with MS for three studies involving transcranial direct current stimulation (tDCS, which involves low electrical current delivered via electrodes). Clinical Trial: Neuroimaging with Transcranial Direct Current Stimulat...
  2. Clinical Trial: A Teleheath tDCS Approach to Decrease Cannabis Use

    Researchers at NYU Langone Health, Multiple Sclerosis Comprehensive Care Center, are recruiting women with RRMS (ages 21 to 65) who regularly use any cannabis product (e.g., marijuana, edibles, vaping) and who wish to reduce cannabis use. The research study will be a one-month...
  3. Clinical Trial: Plant-Derived Oral Cannabinoid Spray to Treat Muscle Spasticity

    SUMMARY: Investigators are recruiting 446 people with MS worldwide who are being treated for spasticity for a study testing whether adding nabiximols (an oral spray), to ongoing antispasticity therapy can reduce MS-related muscle spasms. The study is sponsored by Jazz Pharmace...
  4. Clinical Trial: Exploratory Study of Entire-body PET Scans for Multiple Sclerosis

    Can an entire-body positron emission tomography (PET) scanner be used to improve evaluation, monitoring and measurement of both peripheral and central damage to nerve-insulating myelin (demyelination) in people with MS? We assume here that demyelination outside the brain may i...
  5. Clinical Trial: ReWRAP: Remyelination for Women at Risk for Axonal Loss and Progression

    Dr. Riley Bove and her colleagues at the UCSF Multiple Sclerosis center are conducting a clinical trial to assess the efficacy of bazedoxifene (BZA) in promoting the repair of myelin (remyelination), an important insulating layer for neurons in the central nervous system a...
  6. Clinical Trial: Home-Based Exercise Program for African Americans with MS (TEAAMS)

    The goal of the TEAAMS study is to examine whether a home-based exercise training program can provide improvements in walking dysfunction, symptoms, and quality of life among Black and African Americans with MS who live in the Southeastern US. Participants will exercise at the...
  7. Clinical Trial: Fenebrutinib

    A study to evaluate the effectiveness and safety of fenebrutinib on disability progression and relapse rate. Eligible participants will be randomly assigned to receive either fenebrutinib or teriflunomide. Some may then  receive fenebrutinib during an open label extension.
  8. Clinical Trial: Comparing Experimental Fenebrutinib to Aubagio® in Relapsing MS

     Investigators in the U.S. and abroad are recruiting a total of 1468 people with relapsing forms of MS for two separate studies comparing investigational oral fenebrutinib with Aubagio ® (teriflunomide, Sanofi Genzyme). The studies – also called FENhance – are sponsored by F....
  9. Clinical Trial: Comparing Experimental Fenebrutinib to Ocrevus® in Primary Progressive MS

    Investigators in the U.S. and abroad are recruiting 946 people with primary progressive MS for a study comparing investigational oral fenebrutinib with  Ocrevus ®  (ocrelizumab - Genentech, a member of the Roche Group). The study – also called FENtrepid – is sponsored by F. H...
  10. Clinical Trial: ofatumumab

    A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patient- reported outcomes in people with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy. FDA Approved medication (Brand na...
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