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Emotional Changes


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In addition to its physical symptoms, MS may have profound emotional consequences. At first, it may be difficult to adjust to the diagnosis of a disorder that is unpredictable, has a fluctuating course, and carries a risk of progressing over time to some level of physical disability. Lack of knowledge about the disease adds to the anxieties commonly experienced by people who are newly diagnosed. In addition to these emotional reactions to the disease, demyelination and damage to nerve fibers in the brain can also result in emotional changes. Some of the medications used in MS — such as corticosteroids — can also have significant effects on the emotions.

In the face of MS, people may tend to focus primarily on their physical health and neglect their emotional health—which is an essential component of overall health and wellness.


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Healthy grieving

Grief over any kind of loss is a normal and healthy process. People with MS grieve over changes caused by the disease – beginning with a new diagnosis that alters their life and their self-image – and again whenever the disease causes a significant loss or change —for example of the ability to work, to walk or to engage in certain leisure activities. The grieving process is the first step to learning how to adapt to those changes in one’s life and move forward. Given the many symptoms and changes that MS can cause, a person with MS can expect the normal grieving process to ebb and flow over time.
Grief can sometimes be difficult to distinguish from depression. However, they differ in several ways:
  • Grief over a recent change or loss is generally time-limited and resolves on its own. Clinical depression is more persistent and unremitting, with symptoms lasting at least two weeks and sometimes up to several months.
  • A person experiencing grief may at times be able to focus on life’s activities and gain enjoyment from them, while a person who is depressed may not.
  • Although grief generally resolves on its own without treatment, counseling, self-help groups, as well an understanding and supportive environment can help. Depression requires treatment by a mental health professional. Self-help groups and other types of emotional support are important but not sufficient.

Mood changes

The most common emotional changes in MS include:
  • Grief (and sadness): natural reactions to the changes and/or losses that MS can cause. These feelings will likely ebb and flow over the course of the disease.
  • Worry, fear, moodiness, irritability and anxiety: normal reactions in the face of unpredictability; anyone can become irritable and anxious when faced with difficult challenges.
  • Depression: one of the most common symptoms of MS.
Depression, persistent anxiety and extreme irritability are not natural or inevitable, even in people with MS. However, they are very common. These changes require treatment just like any of the physical symptoms of the disease; mood changes can be a significant source of pain and distress in and of themselves.


Aside from the normal stresses of everyday life, MS creates stresses of its own. Many people with MS say they experience more symptoms during stressful times; when the stress lessens, their symptoms seem less severe. MS is unpredictable and just anticipating the next exacerbation can be a significant source of stress. MS can also lead to some major life changes such as loss of mobility and interference with work

Chronic stress weakens the immune system and increases the risk for a number of illnesses including heart disease, diabetes, and depression. Most research studies about the effects of stress on MS have been inconclusive. Learn more about stress management strategies online.

Researchers have also found that people who experience a moderate amount of hardship throughout their lives show greater well-being and resilience. Resilience is commonly described as the ability to bounce back from difficult circumstances -- to find happiness and life satisfaction despite challenges. Learn more about resilience and how to increase resilience in the face of MS-related challenges.

Generalized anxiety and distress

MS can cause significant anxiety, distress, anger, and frustration from the moment of its very first symptoms. The uncertainty and unpredictability associated with MS is one of its most distressing aspects. In fact, anxiety is at least as common in MS as depression. Loss of functions and altered life circumstances caused by the disease can be significant causes of anxiety and distress.   

Professional counseling and support groups can be very helpful in dealing with the anxiety and distress that may accompany MS. For severe anxiety, medication may also be needed to obtain relief.

Moodiness and irritability

Moodiness and irritability may manifest as rapid and generally unpredictable changes in emotions. Family members may complain about frequent bouts of anger or irritability.

The increase in irritability and moodiness can have multiple causes:
  • Depression
  • Changes in your brain
  • Challenges that can come from living with MS
Whatever the cause, moodiness and irritability can be challenging aspects of MS from the standpoint of family life. Family counseling may be very important in dealing with these emotional changes.

A correct diagnosis of your emotional changes is essential in order to identify the right treatment. While an antidepressant may be the optimal treatment if depression is the cause of your emotional changes, a different type of medication to stabilize your mood might be the best option to help with severe mood shifts and emotional outbursts.
MS and low self-esteem

MS and low self-esteem

We all know that having MS can affect your self-esteem. Check out this one minute infographic for some useful strategies and tips to help boost your confidence and mental health

Less common changes

MS can affect the expression of emotions.

  • Pseudobulbar affect (PBA): experienced by approximately 10 percent of people with MS. Uncontrollable episodes of laughing and/or crying (out of proportion or unrelated to how the person is actually feeling) which may appear to others as depression, but the two conditions are unrelated. The condition is treatable. Nuedexta™ is approved to treat pseudobulbar affect in MS and other neurologic disorders. Counseling and talk therapy have not been shown to be effective treatments for PBA.
  • Euphoria: experienced by a small proportion of people with more advanced MS or significant cognitive changes. A person with euphoria appears to be unrealistically happy, unconcerned about problems, and out of touch with the reality of the situation. This expression of happiness is more related to impairment in cognition than to a mood change.

MS can occasionally cause inappropriate behavior

A very small proportion of people with MS exhibit inappropriate behavior such as sexual disinhibition. This type of behavior is thought to result in part from MS-related damage to the normal inhibitory functions of the brain. These behaviors may also reflect very poor judgment related to cognitive dysfunction caused by MS. Such behavior is generally beyond the control of the individual and is not a sign of moral weakness or sociopathic tendencies.

The treatment of these problems is complex. The person with MS may require some form of psychiatric medication, perhaps along with psychotherapy. Family members will probably need supportive counseling since these behaviors are often shocking and disruptive. In some cases, the affected individual may require supervision to prevent the manifestation of the behaviors in question. 

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