Amitriptyline is a tricyclic antidepressant used to treat depression. In multiple sclerosis it is frequently used to treat painful paresthesias in the arms and legs (e.g., burning sensations, pins and needles, stabbing pains) caused by damage to the pain regulating pathways of the brain and spinal cord.
Note: Other tricyclic antidepressants are also used for the management of neurologic pain symptoms: clomipramine (Anafranil-U.S. and Canada), desipramine (Norpramin-U.S. and Canada), doxepin (Sinequan-U.S. and Canada), imipramine (Tofranil-U.S. and Canada), nortriptyline (Pamelor-U.S.; Aventyl-Canada), trimipramine (U.S. and Canada). While each of these medications is given in different dosage levels, they have similar side effects and precautions.
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