Balo’s Disease

Balo’s disease is a rare demyelinating disorder of the central nervous system (CNS) in which the myelin (the fatty substance covering nerve fibers) is damaged. Balo’s disease shares features with other demyelinating diseases and is generally regarded as a rare variant of multiple sclerosis (MS).
Balo’s disease is also known as Balo disease, encephalitis periaxialis concentrica, leukoencephalitis periaxialis concentrica and concentric sclerosis. The term "concentric sclerosis" comes from a pattern of concentric (circular) areas of damaged myelin alternating with areas of relatively undamaged myelin in various parts of the brain and spinal cord. This pattern can be seen on magnetic resonance imaging (MRI).
Attacks from Balo's disease can proceed rapidly over weeks or months, without remission (a rapidly progressive course); a relapsing course (periods of symptoms followed by improvement or disappearance of symptoms) can also occur, or a person may experience a single attack (monophasic course).