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Progressive-relapsing MS (PRMS)


Progressive-relapsing multiple sclerosis (PRMS) was described in the 1996 disease-course definitions as — steadily worsening neurologic function from the beginning with occasional relapses.

The revised courses – updated from the descriptions first published in 1996 – were developed by the International Advisory Committee on Clinical Trials of MS in 2013, based on advances in the understanding of the disease process in MS and in MRI technology.

Individuals who were previously diagnosed with progressive-relapsing MS would now be considered primary progressive: active (at the time of relapses or new MRI lesions) or not active.


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