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Medicines to Prevent and Treat COVID-19


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Some medicines to prevent COVID-19 pre-exposure and after exposure, as well as to treat COVID-19 infections, have been approved or authorized for use and are available now. Others are being tested. Refer to the National Institutes of Health and for the most up-to-date information.

Pre-exposure prevention of COVID-19


Last updated: March 2, 2022

In December 2021, the U.S. Food and Drug Administration (FDA) authorized Evusheld (tixagevimab co-packaged with cilgavimab) as a medication to prevent COVID-19 in some people ages 12 years and older. This prevention medication is strictly for those who are not expected to have adequate immune responses to the vaccine or who have a severe allergy to it.

As COVID-19 variants continue to emerge, it is not yet known how effective Evusheld will be against each variant. Evusheld is not a substitute for vaccination in individuals for whom vaccination is recommended, and Evusheld is not available for everyone. Consult your MS healthcare provider to determine if Evusheld is right for you.

Learn more and stay abreast of any changes in guidance for this drug on the Evusheld page. Find Evusheld treatment near you.

Post-exposure prevention of COVID-19


REGEN-COV* (casirivimab and imdevimab, administered together) is authorized by the FDA for emergency use as post-exposure prophylaxis (preventative) for COVID-19 in people over the age of 12 who are at high risk for severe COVID-19 (including hospitalization or death).

REGEN-COV is not a substitute for vaccination against COVID-19. Vaccination against COVID-19 continues to be the most effective way to prevent serious illness and decrease the spread of COVID-19. 

REGEN-COV is safe to use with MS disease modifying therapies (DMTs), but the timing might need to be coordinated. People with MS should talk to their MS healthcare provider about whether the use of REGEN-COV is appropriate for them and how to safely time their DMT with it. Find REGEN-COV treatment near you.

*Use of REGEN-COV has been limited by the FDA for infection with or exposure to specific variants.

After contracting COVID-19


The FDA has approved and authorized several treatments for COVID-19. If you have COVID-19, talk with your healthcare provider to determine if these medications are appropriate for you. Find treatment near you.

Early testing for COVID-19 and treatment with antiviral pills can prevent hospital stays. Test-to-Treat sites allow you to get tested as soon as you experience symptoms, get a prescription, if eligible, and start treatment. Find a Test-to-Treat site near you.

Additional resources

Managing MS in a World with COVID-19

Find the resources, information and support you need to live with MS during the ongoing pandemic.

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Disease Modifying Therapy Guidance During COVID-19

Review current recommendations for those taking or considering disease modifying therapies during COVID-19.

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COVID-19 Vaccine Guidance for People Living with MS

Read fact-based guidance about COVID-19 vaccines and MS from researchers and medical professionals.

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La Esclerosis Múltiple y el COVID-19

Obtenga más información sobre las recomendaciones para el tratamiento de la esclerosis múltiple y las vacunas contra el COVID-19.

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